Newer technologies/techniques and tools in the diagnosis of melanoma

Jitendrakumar K. Patel, Sailesh Konda, Oliver A. Perez, Sadegh Amini, George Elgart, Brian Berman

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations


A number of non-invasive approaches have been developed over the years to provide an objective means of evaluating and diagnosing skin melanoma. However, the current gold-standard in melanoma diagnosis is the examination of a skin lesion by the trained eye of a physician followed by histological examination of an invasive excisional biopsy of the skin specimen. Diagnosis of melanoma by simple visual examination is incorrect in almost 1 out of every 3 melanoma diagnoses. Therefore, the diagnosis of early stage in-depth melanoma by non-invasive methods remains an active area of research. Recent advancements in computer and digital technology have provided several sensitive tools to evaluate the different characteristics of a melanoma lesion including its contour, edge, color, size, depth, and/or elevation. These tools include (1) digital imaging systems and computer analysis instruments such as MoleMax™, SIAscope™, SolarScan®, MelaFind™; (2) tape stripping mRNA; (3) laser-based technology such as Confocal scanning laser microscopy (CSLM), optical coherence tomography (OCT), laser Doppler perfusion imaging (LDPI), (4) Ultrasonography, and (5) other imaging tools such as electrical bio-impedance, MRI and PET scan. The ultimate goal of all investigational instrumentation is the prevention of unnecessary biopsies and a decrease in the prevalence and morbidity associated with malignant melanoma.

Original languageEnglish (US)
Pages (from-to)617-631
Number of pages15
JournalEuropean Journal of Dermatology
Issue number6
StatePublished - Nov 1 2008


  • Dermoscope
  • Digital image analysis
  • Melanoma
  • MRI
  • PET scan
  • Ultrasound

ASJC Scopus subject areas

  • Dermatology


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