New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord

Gizelda T B Casella, Alexander Marcillo, Mary B Bunge, Patrick Wood

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Blood vessels identified by laminin staining were studied in uninjured spinal cord and at 2, 4, 7, and 14 days following a moderate contusion (weight drop) injury. At 2 days after injury most blood vessels had been destroyed in the lesion epicenter; neurons and astrocytes were also absent, and few ED1+ cells were seen infiltrating the lesion center. By 4 days, laminin associated with vessel staining was increased and ED1+ cells appeared to be more numerous in the lesion. By 7 days after injury, the new vessels formed a continuous cordon oriented longitudinally through the lesion center. ED1+ cells were abundant at this time point and were found in the same area as the newly formed vessels. Astrocyte migration from the margins of the lesion into the new cordon was apparent. By 14 days, a decrease in the number of vessels in the lesion center was observed; in contrast, astrocytes were more prominent in those areas. In addition to providing a blood supply to the lesion site, protecting the demise of the newly formed vascular bridge might provide an early scaffold to hasten axonal regeneration across the injury site.

Original languageEnglish
Pages (from-to)63-76
Number of pages14
JournalExperimental Neurology
Volume173
Issue number1
DOIs
StatePublished - Jan 30 2002

Fingerprint

Contusions
Blood Vessels
Spinal Cord
Astrocytes
Wounds and Injuries
Laminin
Staining and Labeling
Regeneration
Neurons
Weights and Measures

Keywords

  • Astrocytes
  • Blood vessels
  • Contusion lesion
  • Macrophages
  • Neurons
  • Spinal cord injury

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord. / Casella, Gizelda T B; Marcillo, Alexander; Bunge, Mary B; Wood, Patrick.

In: Experimental Neurology, Vol. 173, No. 1, 30.01.2002, p. 63-76.

Research output: Contribution to journalArticle

Casella, Gizelda T B ; Marcillo, Alexander ; Bunge, Mary B ; Wood, Patrick. / New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord. In: Experimental Neurology. 2002 ; Vol. 173, No. 1. pp. 63-76.
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