New targets for inhibitors of HIV-1 replication

John P. Moore, Mario Stevenson

Research output: Contribution to journalReview article

167 Scopus citations

Abstract

Despite the success of protease and reverse transcriptase inhibitors, new drugs to suppress HIV-1 replication are still needed. Several other early events in the viral life cycle (stages before the viral genome is inserted into host cell DNA) are susceptible to drugs, including virus attachment to target cells, membrane fusion and post-entry events such as integration, accessory-gene function and assembly of viral particles. Among these, inhibitors of virus-cell fusion and integration are the most promising candidates.

Original languageEnglish (US)
Pages (from-to)40-49
Number of pages10
JournalNature Reviews Molecular Cell Biology
Volume1
Issue number1
DOIs
StatePublished - Oct 2000
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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