New targets for inhibitors of HIV-1 replication

John P. Moore, Mario Stevenson

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Despite the success of protease and reverse transcriptase inhibitors, new drugs to suppress HIV-1 replication are still needed. Several other early events in the viral life cycle (stages before the viral genome is inserted into host cell DNA) are susceptible to drugs, including virus attachment to target cells, membrane fusion and post-entry events such as integration, accessory-gene function and assembly of viral particles. Among these, inhibitors of virus-cell fusion and integration are the most promising candidates.

Original languageEnglish
Pages (from-to)40-49
Number of pages10
JournalNature Reviews Molecular Cell Biology
Volume1
Issue number1
StatePublished - Oct 1 2000
Externally publishedYes

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Cell Fusion
HIV-1
Virus Attachment
Membrane Fusion
Reverse Transcriptase Inhibitors
Viral Genome
Life Cycle Stages
Pharmaceutical Preparations
Virion
Peptide Hydrolases
Cell Membrane
Viruses
DNA
Genes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

New targets for inhibitors of HIV-1 replication. / Moore, John P.; Stevenson, Mario.

In: Nature Reviews Molecular Cell Biology, Vol. 1, No. 1, 01.10.2000, p. 40-49.

Research output: Contribution to journalArticle

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