New styrene-b-isobutylene-b-styrene (SIBS) glaucoma drainage implant

Marcia Orozco, Ana C. Acosta, Edgar M. Espana, Leonard Pinchuk, Bruce Weber, Stewart Davis, Esdras Arrieta, Sander Dubovy, Francisco Fantes, Mohamed Aly, Yonghua Zhou, Jean Marie Parel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Purpose: To design and test the Miami-InnFocus Drainage Implant (MiDi) as a glaucoma shunt that is biocompatible, flexible, and significantly smaller than existing commercial implants in order to prevent postoperative hypotony, inflammation, scarring, erosion, and extrusion. Methods: A new biomaterial composed of styrene-b-isobutylene-b-styrene (SIBS) was used in a novel design for a glaucoma drainage implant. The implant consists of a tube 11mm long with an inner diameter of 70, 100, and 150 μm and outer diameter of 250 μm with a 1mm 2 tab located 4.5mm from the proximal tip to prevent migration. The device was implanted in 15 New Zealand White rabbits for biocompatibility and efficacy testing. A similarly designed implant made of polydimethylsiloxane was implanted in 6 other animals as a pseudo-control. Typical GDI implantation technique was modified for this device. The proximal end of the new SIBS implant was inserted 2mm into the anterior chamber and the distal end placed in a subconjunctival space created by the surgeon. Biocompatibility of the device was studied by slit-lamp follow-up and intraocular pressure (IOP) measurements recorded periodically. Results: Biocompatibility of the MiDi was excellent. A low and diffuse bleb was observed with these devices. All SIBS tubes were patent 9 months after insertion. Immunostaining demonstrated non-continuous deposition of collagen with virtually no encapsulation. No macrophages or myofibroblast were visible around the SIBS polymer which was found more bioinert than the control PDMS. Conclusion: This newly designed glaucoma implant is clinically biocompatible in the rabbit model and maintained 100% patency at 9 months.

Original languageEnglish (US)
Title of host publicationOphthalmic Technologies XVI
DOIs
StatePublished - Jun 30 2006
EventOphthalmic Technologies XVI - San Jose, CA, United States
Duration: Jan 21 2006Jan 24 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6138
ISSN (Print)1605-7422

Other

OtherOphthalmic Technologies XVI
CountryUnited States
CitySan Jose, CA
Period1/21/061/24/06

Keywords

  • Aqueous
  • Biocompatibility
  • Intraocular pressure
  • Wound healing

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Orozco, M., Acosta, A. C., Espana, E. M., Pinchuk, L., Weber, B., Davis, S., Arrieta, E., Dubovy, S., Fantes, F., Aly, M., Zhou, Y., & Parel, J. M. (2006). New styrene-b-isobutylene-b-styrene (SIBS) glaucoma drainage implant. In Ophthalmic Technologies XVI [61380U] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6138). https://doi.org/10.1117/12.652297