New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci

David Watkins, Stephen N. McAdam, Xiaomin Liu, Clarice R. Strang, Edgar L. Milford, Cindy G. Levine, Theodore L. Garbert, Alex L. Dogon, Carol I. Lord, Steven H. Ghim, Gary M. Troup, Austin L. Hughes, Norman L. Letvin

Research output: Contribution to journalArticle

217 Citations (Scopus)

Abstract

EVIDENCE suggests that the New World was colonized only 11,000-40,000 years ago by Palaeo-Indians1. The descendants of these Palaeo-Indians therefore provide a unique opportunity to study the effects of selection on major histocompatibility complex class I genes over a short period. Here we analyse the class I alleles of the Waorani of South America and the Zuni of North America. Four of the Waorani HLA-B alleles were new functional variants which could be accounted for by intralocus recombination. In contrast, all of the Zuni HLA-A and -B molecules were present in Caucasians and orientals. This suggests that the new Waorani HLA-B variants arose in South America. The description of four new HLA-B alleles in the Waorani and another five new HLA-B alleles from two other tribes of South American Amerindians2 indicates that the HLA-B locus can evolve rapidly in isolated populations. These studies underline the importance of gathering genetic data on endangered native human populations3.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalNature
Volume357
Issue number6376
StatePublished - May 28 1992
Externally publishedYes

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HLA-B Antigens
Population Groups
Alleles
South America
MHC Class I Genes
HLA-A Antigens
North America
Major Histocompatibility Complex
Genetic Recombination
Population

ASJC Scopus subject areas

  • General

Cite this

Watkins, D., McAdam, S. N., Liu, X., Strang, C. R., Milford, E. L., Levine, C. G., ... Letvin, N. L. (1992). New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci. Nature, 357(6376), 329-333.

New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci. / Watkins, David; McAdam, Stephen N.; Liu, Xiaomin; Strang, Clarice R.; Milford, Edgar L.; Levine, Cindy G.; Garbert, Theodore L.; Dogon, Alex L.; Lord, Carol I.; Ghim, Steven H.; Troup, Gary M.; Hughes, Austin L.; Letvin, Norman L.

In: Nature, Vol. 357, No. 6376, 28.05.1992, p. 329-333.

Research output: Contribution to journalArticle

Watkins, D, McAdam, SN, Liu, X, Strang, CR, Milford, EL, Levine, CG, Garbert, TL, Dogon, AL, Lord, CI, Ghim, SH, Troup, GM, Hughes, AL & Letvin, NL 1992, 'New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci', Nature, vol. 357, no. 6376, pp. 329-333.
Watkins D, McAdam SN, Liu X, Strang CR, Milford EL, Levine CG et al. New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci. Nature. 1992 May 28;357(6376):329-333.
Watkins, David ; McAdam, Stephen N. ; Liu, Xiaomin ; Strang, Clarice R. ; Milford, Edgar L. ; Levine, Cindy G. ; Garbert, Theodore L. ; Dogon, Alex L. ; Lord, Carol I. ; Ghim, Steven H. ; Troup, Gary M. ; Hughes, Austin L. ; Letvin, Norman L. / New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci. In: Nature. 1992 ; Vol. 357, No. 6376. pp. 329-333.
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