New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic β-cell

P. R. Flatt, O. Shibier, J. Szecowka, P. O. Berggren

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Sulphonylureas and the hyperglycaemic sulphonamide diazoxide are commonly employed in the therapy of non-insulin-dependent (Type 2) diabetes mellitus and insulinoma, respectively. Stimulatory effects of sulphonylureas on insulin secretion and the inhibitory action of diazoxide are thought to be primarily mediated through modulation of the activity of ATP-sensitive K+ channels (K+-ATP channels) in the β-cell plasma membrane. Certain sulphonylureas are known to be internalised by the pancreatic B-cell. Recent studies suggest that these drugs and diazoxide can influence insulin secretion from electropermeabilised β-cells in which K+-ATP channels and other plasma membrane ion channels are inoperative. This observation suggests that sulphonylureas and diazoxide interact with intracellular sites in the pancreatic B-cell which are directly involved in the regulation of the final stages of exocytosis.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalDiabete et Metabolisme
Volume20
Issue number2
StatePublished - Dec 1 1994
Externally publishedYes

Fingerprint

Diazoxide
Sulfonamides
Adenosine Triphosphate
Cell Membrane
Insulin-Secreting Cells
Ion Channels
Insulin
Insulinoma
Exocytosis
Type 2 Diabetes Mellitus
Pharmaceutical Preparations

Keywords

  • diazoxide
  • electropermeabilisation
  • exocytosis
  • insulin secretion
  • pancreatic β-cell
  • sulphonylureas

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Flatt, P. R., Shibier, O., Szecowka, J., & Berggren, P. O. (1994). New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic β-cell. Diabete et Metabolisme, 20(2), 157-162.

New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic β-cell. / Flatt, P. R.; Shibier, O.; Szecowka, J.; Berggren, P. O.

In: Diabete et Metabolisme, Vol. 20, No. 2, 01.12.1994, p. 157-162.

Research output: Contribution to journalArticle

Flatt, PR, Shibier, O, Szecowka, J & Berggren, PO 1994, 'New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic β-cell', Diabete et Metabolisme, vol. 20, no. 2, pp. 157-162.
Flatt, P. R. ; Shibier, O. ; Szecowka, J. ; Berggren, P. O. / New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic β-cell. In: Diabete et Metabolisme. 1994 ; Vol. 20, No. 2. pp. 157-162.
@article{d9232bc5755145efb1fbf671b9f6a056,
title = "New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic β-cell",
abstract = "Sulphonylureas and the hyperglycaemic sulphonamide diazoxide are commonly employed in the therapy of non-insulin-dependent (Type 2) diabetes mellitus and insulinoma, respectively. Stimulatory effects of sulphonylureas on insulin secretion and the inhibitory action of diazoxide are thought to be primarily mediated through modulation of the activity of ATP-sensitive K+ channels (K+-ATP channels) in the β-cell plasma membrane. Certain sulphonylureas are known to be internalised by the pancreatic B-cell. Recent studies suggest that these drugs and diazoxide can influence insulin secretion from electropermeabilised β-cells in which K+-ATP channels and other plasma membrane ion channels are inoperative. This observation suggests that sulphonylureas and diazoxide interact with intracellular sites in the pancreatic B-cell which are directly involved in the regulation of the final stages of exocytosis.",
keywords = "diazoxide, electropermeabilisation, exocytosis, insulin secretion, pancreatic β-cell, sulphonylureas",
author = "Flatt, {P. R.} and O. Shibier and J. Szecowka and Berggren, {P. O.}",
year = "1994",
month = "12",
day = "1",
language = "English",
volume = "20",
pages = "157--162",
journal = "Diabetes and Metabolism",
issn = "1262-3636",
publisher = "Elsevier Masson",
number = "2",

}

TY - JOUR

T1 - New perspectives on the actions of sulphonylureas and hyperglycaemic sulphonamides on the pancreatic β-cell

AU - Flatt, P. R.

AU - Shibier, O.

AU - Szecowka, J.

AU - Berggren, P. O.

PY - 1994/12/1

Y1 - 1994/12/1

N2 - Sulphonylureas and the hyperglycaemic sulphonamide diazoxide are commonly employed in the therapy of non-insulin-dependent (Type 2) diabetes mellitus and insulinoma, respectively. Stimulatory effects of sulphonylureas on insulin secretion and the inhibitory action of diazoxide are thought to be primarily mediated through modulation of the activity of ATP-sensitive K+ channels (K+-ATP channels) in the β-cell plasma membrane. Certain sulphonylureas are known to be internalised by the pancreatic B-cell. Recent studies suggest that these drugs and diazoxide can influence insulin secretion from electropermeabilised β-cells in which K+-ATP channels and other plasma membrane ion channels are inoperative. This observation suggests that sulphonylureas and diazoxide interact with intracellular sites in the pancreatic B-cell which are directly involved in the regulation of the final stages of exocytosis.

AB - Sulphonylureas and the hyperglycaemic sulphonamide diazoxide are commonly employed in the therapy of non-insulin-dependent (Type 2) diabetes mellitus and insulinoma, respectively. Stimulatory effects of sulphonylureas on insulin secretion and the inhibitory action of diazoxide are thought to be primarily mediated through modulation of the activity of ATP-sensitive K+ channels (K+-ATP channels) in the β-cell plasma membrane. Certain sulphonylureas are known to be internalised by the pancreatic B-cell. Recent studies suggest that these drugs and diazoxide can influence insulin secretion from electropermeabilised β-cells in which K+-ATP channels and other plasma membrane ion channels are inoperative. This observation suggests that sulphonylureas and diazoxide interact with intracellular sites in the pancreatic B-cell which are directly involved in the regulation of the final stages of exocytosis.

KW - diazoxide

KW - electropermeabilisation

KW - exocytosis

KW - insulin secretion

KW - pancreatic β-cell

KW - sulphonylureas

UR - http://www.scopus.com/inward/record.url?scp=0028610124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028610124&partnerID=8YFLogxK

M3 - Article

C2 - 7805953

AN - SCOPUS:0028610124

VL - 20

SP - 157

EP - 162

JO - Diabetes and Metabolism

JF - Diabetes and Metabolism

SN - 1262-3636

IS - 2

ER -