Nuove ipotesi patogenetiche e diagnostiche sulla tiroidite di Hashimoto

Translated title of the contribution: New pathogenetic and diagnostic hypotheses on Hashimoto's thyroiditis

A. Signore, M. A. Mosetti, P. Giacalone, G. Di Leve, G. Capriotti, M. G. Parisella, A. Paggi

Research output: Contribution to journalArticlepeer-review


The Authors studied and summarized the most recent findings of scientific literature on the pathogenesis of Hashimoto's thyroiditis and reported their experience concerning the new diagnostic possibilities. The study of apoptosis, the programmed cell death, as a mechanism for destruction of follicular cells in autoimmune thyroid disease, has been particularly investigated. The FAS receptor and the FAS ligand acting as important components for this mechanism have been identified: IL1β, abundantly produced in the inflammatory process, induces FAS expression in thyrocytes, therefore causing the cellular destruction in Hashimoto's thyroiditis. The Authors have finally reviewed the use of the (99m)TC-IL-2 scintigraphy for Hashimoto's thyroiditis diagnosis and follow-up.

Translated title of the contributionNew pathogenetic and diagnostic hypotheses on Hashimoto's thyroiditis
Original languageItalian
Pages (from-to)63-66
Number of pages4
JournalPoliclinico - Sezione Medica
Issue number2
StatePublished - 1998
Externally publishedYes


  • Apoptosis
  • FAS
  • FASL
  • Hashimoto's thyroiditis

ASJC Scopus subject areas

  • Medicine(all)


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