The Authors studied and summarized the most recent findings of scientific literature on the pathogenesis of Hashimoto's thyroiditis and reported their experience concerning the new diagnostic possibilities. The study of apoptosis, the programmed cell death, as a mechanism for destruction of follicular cells in autoimmune thyroid disease, has been particularly investigated. The FAS receptor and the FAS ligand acting as important components for this mechanism have been identified: IL1β, abundantly produced in the inflammatory process, induces FAS expression in thyrocytes, therefore causing the cellular destruction in Hashimoto's thyroiditis. The Authors have finally reviewed the use of the (99m)TC-IL-2 scintigraphy for Hashimoto's thyroiditis diagnosis and follow-up.
|Translated title of the contribution||New pathogenetic and diagnostic hypotheses on Hashimoto's thyroiditis|
|Number of pages||4|
|Journal||Policlinico - Sezione Medica|
|State||Published - 1998|
- Hashimoto's thyroiditis
ASJC Scopus subject areas