New insights into the mechanisms controlling urea excretion in fish gills

Danielle M Mcdonald, Kathleen M. Gilmour, Patrick J. Walsh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Not long ago, urea was believed to freely diffuse across plasma membranes. The discovery of specialized proteins to facilitate the movement of urea across the fish gill, similar to those found in mammalian kidney, was exciting, and at the same time, perplexing; especially considering the fact that, aside from elasmobranchs, most fish do not produce urea as their primary nitrogenous waste. Increasingly, it has become apparent that many fish do indeed produce at least a small amount of urea through various processes and continued work on branchial urea transporters in teleost and elasmobranch fishes has led to recent advances in the regulation of these mechanisms. The following review outlines the substantial progress that has been made towards understanding environmental and developmental impacts on fish gill urea transport. This review also outlines the work that has been done regarding endocrine and neural control of urea excretion, most of which has been collected from only a handful of teleost fish. It is evident that more research is needed to establish the endocrine and neural control of urea excretion in fish, including fish representative of more ancient lineages (hagfish and lamprey), and elasmobranch fish.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalRespiratory Physiology and Neurobiology
Volume184
Issue number3
DOIs
StatePublished - Dec 1 2012

Fingerprint

Urea
Fishes
Elasmobranchii
Hagfishes
Lampreys
Cell Membrane
Kidney
Research
Proteins

Keywords

  • Carbon dioxide
  • Cortisol
  • Development
  • Elasmobranchs
  • Facilitated diffusion
  • Fluoxetine
  • Hypoxia
  • Salinity
  • Serotonin
  • Teleosts
  • Urea transport

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

New insights into the mechanisms controlling urea excretion in fish gills. / Mcdonald, Danielle M; Gilmour, Kathleen M.; Walsh, Patrick J.

In: Respiratory Physiology and Neurobiology, Vol. 184, No. 3, 01.12.2012, p. 241-248.

Research output: Contribution to journalArticle

Mcdonald, Danielle M ; Gilmour, Kathleen M. ; Walsh, Patrick J. / New insights into the mechanisms controlling urea excretion in fish gills. In: Respiratory Physiology and Neurobiology. 2012 ; Vol. 184, No. 3. pp. 241-248.
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