Abstract
Not long ago, urea was believed to freely diffuse across plasma membranes. The discovery of specialized proteins to facilitate the movement of urea across the fish gill, similar to those found in mammalian kidney, was exciting, and at the same time, perplexing; especially considering the fact that, aside from elasmobranchs, most fish do not produce urea as their primary nitrogenous waste. Increasingly, it has become apparent that many fish do indeed produce at least a small amount of urea through various processes and continued work on branchial urea transporters in teleost and elasmobranch fishes has led to recent advances in the regulation of these mechanisms. The following review outlines the substantial progress that has been made towards understanding environmental and developmental impacts on fish gill urea transport. This review also outlines the work that has been done regarding endocrine and neural control of urea excretion, most of which has been collected from only a handful of teleost fish. It is evident that more research is needed to establish the endocrine and neural control of urea excretion in fish, including fish representative of more ancient lineages (hagfish and lamprey), and elasmobranch fish.
| Original language | English |
|---|---|
| Pages (from-to) | 241-248 |
| Number of pages | 8 |
| Journal | Respiratory Physiology and Neurobiology |
| Volume | 184 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1 2012 |
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Keywords
- Carbon dioxide
- Cortisol
- Development
- Elasmobranchs
- Facilitated diffusion
- Fluoxetine
- Hypoxia
- Salinity
- Serotonin
- Teleosts
- Urea transport
ASJC Scopus subject areas
- Physiology
- Pulmonary and Respiratory Medicine
- Neuroscience(all)
Cite this
New insights into the mechanisms controlling urea excretion in fish gills. / Mcdonald, Danielle M; Gilmour, Kathleen M.; Walsh, Patrick J.
In: Respiratory Physiology and Neurobiology, Vol. 184, No. 3, 01.12.2012, p. 241-248.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New insights into the mechanisms controlling urea excretion in fish gills
AU - Mcdonald, Danielle M
AU - Gilmour, Kathleen M.
AU - Walsh, Patrick J.
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Not long ago, urea was believed to freely diffuse across plasma membranes. The discovery of specialized proteins to facilitate the movement of urea across the fish gill, similar to those found in mammalian kidney, was exciting, and at the same time, perplexing; especially considering the fact that, aside from elasmobranchs, most fish do not produce urea as their primary nitrogenous waste. Increasingly, it has become apparent that many fish do indeed produce at least a small amount of urea through various processes and continued work on branchial urea transporters in teleost and elasmobranch fishes has led to recent advances in the regulation of these mechanisms. The following review outlines the substantial progress that has been made towards understanding environmental and developmental impacts on fish gill urea transport. This review also outlines the work that has been done regarding endocrine and neural control of urea excretion, most of which has been collected from only a handful of teleost fish. It is evident that more research is needed to establish the endocrine and neural control of urea excretion in fish, including fish representative of more ancient lineages (hagfish and lamprey), and elasmobranch fish.
AB - Not long ago, urea was believed to freely diffuse across plasma membranes. The discovery of specialized proteins to facilitate the movement of urea across the fish gill, similar to those found in mammalian kidney, was exciting, and at the same time, perplexing; especially considering the fact that, aside from elasmobranchs, most fish do not produce urea as their primary nitrogenous waste. Increasingly, it has become apparent that many fish do indeed produce at least a small amount of urea through various processes and continued work on branchial urea transporters in teleost and elasmobranch fishes has led to recent advances in the regulation of these mechanisms. The following review outlines the substantial progress that has been made towards understanding environmental and developmental impacts on fish gill urea transport. This review also outlines the work that has been done regarding endocrine and neural control of urea excretion, most of which has been collected from only a handful of teleost fish. It is evident that more research is needed to establish the endocrine and neural control of urea excretion in fish, including fish representative of more ancient lineages (hagfish and lamprey), and elasmobranch fish.
KW - Carbon dioxide
KW - Cortisol
KW - Development
KW - Elasmobranchs
KW - Facilitated diffusion
KW - Fluoxetine
KW - Hypoxia
KW - Salinity
KW - Serotonin
KW - Teleosts
KW - Urea transport
UR - http://www.scopus.com/inward/record.url?scp=84869155457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869155457&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2012.06.002
DO - 10.1016/j.resp.2012.06.002
M3 - Article
C2 - 22684040
AN - SCOPUS:84869155457
VL - 184
SP - 241
EP - 248
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 3
ER -