New insights into the architecture of the islet of Langerhans: a focused cross-species assessment

Rafael Arrojo e Drigo, Yusuf Ali, Juan Diez, Dinesh Kumar Srinivasan, Per Olof Berggren, Bernhard O. Boehm

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

The human genome project and its search for factors underlying human diseases has fostered a major human research effort. Therefore, unsurprisingly, in recent years we have observed an increasing number of studies on human islet cells, including disease approaches focusing on type 1 and type 2 diabetes. Yet, the field of islet and diabetes research relies on the legacy of rodent-based investigations, which have proven difficult to translate to humans, particularly in type 1 diabetes. Whole islet physiology and pathology may differ between rodents and humans, and thus a comprehensive cross-species as well as species-specific view on islet research is much needed. In this review we summarise the current knowledge of interspecies islet cytoarchitecture, and discuss its potential impact on islet function and future perspectives in islet pathophysiology research.

Original languageEnglish (US)
Pages (from-to)2218-2228
Number of pages11
JournalDiabetologia
Volume58
Issue number10
DOIs
StatePublished - Oct 24 2015

Keywords

  • Cross-species assessment
  • Intra-islet signalling
  • Islet cell architecture
  • Islets of Langerhans
  • Non-human primates
  • Review

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Arrojo e Drigo, R., Ali, Y., Diez, J., Srinivasan, D. K., Berggren, P. O., & Boehm, B. O. (2015). New insights into the architecture of the islet of Langerhans: a focused cross-species assessment. Diabetologia, 58(10), 2218-2228. https://doi.org/10.1007/s00125-015-3699-0