New Insight on Human Type 1 Diabetes Biology: nPOD and nPOD-Transplantation

Alberto Pugliese, Francesco Vendrame, Helena Reijonen, Mark A. Atkinson, Martha Campbell-Thompson, George W. Burke

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

The Juvenile Diabetes Research Foundation (JDRF) Network for Pancreatic Organ Donors with Diabetes (JDRF nPOD) was established to obtain human pancreata and other tissues from organ donors with type 1 diabetes (T1D) in support of research focused on disease pathogenesis. Since 2007, nPOD has recovered tissues from over 100 T1D donors and distributed specimens to approximately 130 projects led by investigators worldwide. More recently, nPOD established a programmatic expansion that further links the transplantation world to nPOD, nPOD-Transplantation; this effort is pioneering novel approaches to extend the study of islet autoimmunity to the transplanted pancreas and to consent patients for postmortem organ donation directed towards diabetes research. Finally, nPOD actively fosters and coordinates collaborative research among nPOD investigators, with the formation of working groups and the application of team science approaches. Exciting findings are emerging from the collective work of nPOD investigators, which covers multiple aspects of islet autoimmunity and beta cell biology.

Original languageEnglish (US)
Article number530
JournalCurrent diabetes reports
Volume14
Issue number10
DOIs
StatePublished - Sep 12 2014

Keywords

  • nPOD
  • Pancreas
  • Transplantation
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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