New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Equilibrium, creep, and dynamic behaviors of agarose gels (2.0-14.8%) in confined compression were investigated in this study. The hydraulic permeabilities of gels were determined by curve-fitting creep data to the biphasic model (J. Biomech. Eng. 102 (1980) 73) and found to be similar in value to those published in the literature (AIChE J. 42 (1996) 1220). A new relationship between intrinsic permeability and volume fraction of water was found for agarose gel, capable of predicting deformation-dependent permeabilities of bovine articular cartilage and 2% agarose gel published in literature. This relationship is accurate for gels and cartilage over a wide range of permeabilities (four orders of magnitude variation). The dynamic stiffness of the gels increases with gel concentration and loading frequency (0.01-1.0Hz). The increase in dynamic stiffness with loading frequency is less pronounced for gels with higher concentrations. The results of this study provide a new insight into deformation-dependent permeability behavior of agarose gel and cartilage, and are important for understanding biological responses of cells to interstitial fluid flow in gel or in cartilage under dynamic mechanical loading.

Original languageEnglish
Pages (from-to)593-598
Number of pages6
JournalJournal of Biomechanics
Volume36
Issue number4
DOIs
StatePublished - Apr 1 2003

Fingerprint

Cartilage
Sepharose
Permeability
Gels
Hydraulics
Creep
Stiffness
Extracellular Fluid
Curve fitting
Articular Cartilage
Flow of fluids
Volume fraction
Water

Keywords

  • Agarose gel
  • Articular cartilage
  • Dynamic compression
  • Hydraulic permeability
  • Soft tissue mechanics

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

@article{bfb79203d9cf45aba58058d39dd1fe0f,
title = "New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression",
abstract = "Equilibrium, creep, and dynamic behaviors of agarose gels (2.0-14.8{\%}) in confined compression were investigated in this study. The hydraulic permeabilities of gels were determined by curve-fitting creep data to the biphasic model (J. Biomech. Eng. 102 (1980) 73) and found to be similar in value to those published in the literature (AIChE J. 42 (1996) 1220). A new relationship between intrinsic permeability and volume fraction of water was found for agarose gel, capable of predicting deformation-dependent permeabilities of bovine articular cartilage and 2{\%} agarose gel published in literature. This relationship is accurate for gels and cartilage over a wide range of permeabilities (four orders of magnitude variation). The dynamic stiffness of the gels increases with gel concentration and loading frequency (0.01-1.0Hz). The increase in dynamic stiffness with loading frequency is less pronounced for gels with higher concentrations. The results of this study provide a new insight into deformation-dependent permeability behavior of agarose gel and cartilage, and are important for understanding biological responses of cells to interstitial fluid flow in gel or in cartilage under dynamic mechanical loading.",
keywords = "Agarose gel, Articular cartilage, Dynamic compression, Hydraulic permeability, Soft tissue mechanics",
author = "Weiyong Gu and H. Yao and Chun-Yuh Huang and Cheung, {Herman S}",
year = "2003",
month = "4",
day = "1",
doi = "10.1016/S0021-9290(02)00437-2",
language = "English",
volume = "36",
pages = "593--598",
journal = "Journal of Biomechanics",
issn = "0021-9290",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression

AU - Gu, Weiyong

AU - Yao, H.

AU - Huang, Chun-Yuh

AU - Cheung, Herman S

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Equilibrium, creep, and dynamic behaviors of agarose gels (2.0-14.8%) in confined compression were investigated in this study. The hydraulic permeabilities of gels were determined by curve-fitting creep data to the biphasic model (J. Biomech. Eng. 102 (1980) 73) and found to be similar in value to those published in the literature (AIChE J. 42 (1996) 1220). A new relationship between intrinsic permeability and volume fraction of water was found for agarose gel, capable of predicting deformation-dependent permeabilities of bovine articular cartilage and 2% agarose gel published in literature. This relationship is accurate for gels and cartilage over a wide range of permeabilities (four orders of magnitude variation). The dynamic stiffness of the gels increases with gel concentration and loading frequency (0.01-1.0Hz). The increase in dynamic stiffness with loading frequency is less pronounced for gels with higher concentrations. The results of this study provide a new insight into deformation-dependent permeability behavior of agarose gel and cartilage, and are important for understanding biological responses of cells to interstitial fluid flow in gel or in cartilage under dynamic mechanical loading.

AB - Equilibrium, creep, and dynamic behaviors of agarose gels (2.0-14.8%) in confined compression were investigated in this study. The hydraulic permeabilities of gels were determined by curve-fitting creep data to the biphasic model (J. Biomech. Eng. 102 (1980) 73) and found to be similar in value to those published in the literature (AIChE J. 42 (1996) 1220). A new relationship between intrinsic permeability and volume fraction of water was found for agarose gel, capable of predicting deformation-dependent permeabilities of bovine articular cartilage and 2% agarose gel published in literature. This relationship is accurate for gels and cartilage over a wide range of permeabilities (four orders of magnitude variation). The dynamic stiffness of the gels increases with gel concentration and loading frequency (0.01-1.0Hz). The increase in dynamic stiffness with loading frequency is less pronounced for gels with higher concentrations. The results of this study provide a new insight into deformation-dependent permeability behavior of agarose gel and cartilage, and are important for understanding biological responses of cells to interstitial fluid flow in gel or in cartilage under dynamic mechanical loading.

KW - Agarose gel

KW - Articular cartilage

KW - Dynamic compression

KW - Hydraulic permeability

KW - Soft tissue mechanics

UR - http://www.scopus.com/inward/record.url?scp=0037398425&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037398425&partnerID=8YFLogxK

U2 - 10.1016/S0021-9290(02)00437-2

DO - 10.1016/S0021-9290(02)00437-2

M3 - Article

C2 - 12600349

AN - SCOPUS:0037398425

VL - 36

SP - 593

EP - 598

JO - Journal of Biomechanics

JF - Journal of Biomechanics

SN - 0021-9290

IS - 4

ER -