NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN

A. Grossman, L. Perry, Andrew V Schally, LesleyH Rees, A. C. Nieuwenhuyzen Kruseman, Susan Tomlin, D. H. Coy, Ana Maria Comaru-Schally, G. M. Besser

Research output: Contribution to journalArticle

169 Citations (Scopus)

Abstract

A synthetic preparation of the 41-aminoacid-residue peptide recently isolated from ovine hypothalami and characterised corticotropin-releasing factor (CRF), has been given intravenously to six normal men. 100 μg synthetic CRF caused rises in circulating levels of adrenocorticotropic hormone (ACTH) and cortisol but had no effect on levels of prolactin, growth hormone, thyrotropin, or gonadotropins. Its specific action suggests that it, or a related peptide, may be a CRF in man, and it may provide the basis for a new clinical test of pituitary ACTH reserve.

Original languageEnglish
Pages (from-to)921-922
Number of pages2
JournalThe Lancet
Volume319
Issue number8278
DOIs
StatePublished - Apr 24 1982
Externally publishedYes

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Hypothalamic Hormones
Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Hydrocortisone
Peptides
Pituitary Hormones
Thyrotropin
Gonadotropins
Prolactin
Growth Hormone
Hypothalamus
Sheep

ASJC Scopus subject areas

  • Medicine(all)

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NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN. / Grossman, A.; Perry, L.; Schally, Andrew V; Rees, LesleyH; Nieuwenhuyzen Kruseman, A. C.; Tomlin, Susan; Coy, D. H.; Comaru-Schally, Ana Maria; Besser, G. M.

In: The Lancet, Vol. 319, No. 8278, 24.04.1982, p. 921-922.

Research output: Contribution to journalArticle

Grossman, A, Perry, L, Schally, AV, Rees, L, Nieuwenhuyzen Kruseman, AC, Tomlin, S, Coy, DH, Comaru-Schally, AM & Besser, GM 1982, 'NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN', The Lancet, vol. 319, no. 8278, pp. 921-922. https://doi.org/10.1016/S0140-6736(82)91929-8
Grossman, A. ; Perry, L. ; Schally, Andrew V ; Rees, LesleyH ; Nieuwenhuyzen Kruseman, A. C. ; Tomlin, Susan ; Coy, D. H. ; Comaru-Schally, Ana Maria ; Besser, G. M. / NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN. In: The Lancet. 1982 ; Vol. 319, No. 8278. pp. 921-922.
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