NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN

A. Grossman, L. Perry, A. V. Schally, Lesley H. Rees, A. C. Nieuwenhuyzen Kruseman, Susan Tomlin, D. H. Coy, Ana Maria Comaru-Schally, G. M. Besser

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Abstract

A synthetic preparation of the 41-aminoacid-residue peptide recently isolated from ovine hypothalami and characterised corticotropin-releasing factor (CRF), has been given intravenously to six normal men. 100 μg synthetic CRF caused rises in circulating levels of adrenocorticotropic hormone (ACTH) and cortisol but had no effect on levels of prolactin, growth hormone, thyrotropin, or gonadotropins. Its specific action suggests that it, or a related peptide, may be a CRF in man, and it may provide the basis for a new clinical test of pituitary ACTH reserve.

Original languageEnglish (US)
Pages (from-to)921-922
Number of pages2
JournalThe Lancet
Volume319
Issue number8278
DOIs
StatePublished - Apr 24 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Grossman, A., Perry, L., Schally, A. V., Rees, L. H., Nieuwenhuyzen Kruseman, A. C., Tomlin, S., Coy, D. H., Comaru-Schally, A. M., & Besser, G. M. (1982). NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN. The Lancet, 319(8278), 921-922. https://doi.org/10.1016/S0140-6736(82)91929-8