New horizons in the analysis of circulating cell-derived microparticles

Lawrence L. Horstman, Wenche Jy, Joaquin J. Jimenez, Carlos Bidot, Yeon S. Ahn

Research output: Contribution to journalReview article

126 Scopus citations

Abstract

Analysis of circulating cell-derived microparticles (MP) is becoming more refined and clinically useful. This review, stemming from lectures given at Tokyo late 2003, does not repeat prior reviews but focusses on new horizons. A major theme is the rising recognition of platelets and their MP (PMP) as key mediators of inflammation/immunity. Among the major concepts developed are that (i) many so-called soluble markers of inflammation are in reality MP-bound; (ii) PMP and other MP appear to serve important signaling and immune functions including antigen presentation. In conclusion, MP analysis is poised to enter the mainstream of clinical testing, measuring specific antigens rather than gross levels. However, more research is needed to decisively establish their functions, and international standards are needed to allow comparing results from different laboratories.

Original languageEnglish (US)
Pages (from-to)210-230
Number of pages21
JournalKeio Journal of Medicine
Volume53
Issue number4
DOIs
StatePublished - Dec 1 2004

Keywords

  • Cell-derived microparticles
  • Inflammation
  • Platelet microparticles

ASJC Scopus subject areas

  • Medicine(all)

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