New horizons in the analysis of circulating cell-derived microparticles

Lawrence L. Horstman, Wenche Jy, Joaquin J Jimenez, Carlos Bidot, Yeon Ahn

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Analysis of circulating cell-derived microparticles (MP) is becoming more refined and clinically useful. This review, stemming from lectures given at Tokyo late 2003, does not repeat prior reviews but focusses on new horizons. A major theme is the rising recognition of platelets and their MP (PMP) as key mediators of inflammation/immunity. Among the major concepts developed are that (i) many so-called soluble markers of inflammation are in reality MP-bound; (ii) PMP and other MP appear to serve important signaling and immune functions including antigen presentation. In conclusion, MP analysis is poised to enter the mainstream of clinical testing, measuring specific antigens rather than gross levels. However, more research is needed to decisively establish their functions, and international standards are needed to allow comparing results from different laboratories.

Original languageEnglish
Pages (from-to)210-230
Number of pages21
JournalKeio Journal of Medicine
Volume53
Issue number4
DOIs
StatePublished - Dec 1 2004

Fingerprint

Cell-Derived Microparticles
Blood Platelets
Inflammation Mediators
Tokyo
Antigen Presentation
Immunity
Inflammation
Antigens
Research

Keywords

  • Cell-derived microparticles
  • Inflammation
  • Platelet microparticles

ASJC Scopus subject areas

  • Medicine(all)

Cite this

New horizons in the analysis of circulating cell-derived microparticles. / Horstman, Lawrence L.; Jy, Wenche; Jimenez, Joaquin J; Bidot, Carlos; Ahn, Yeon.

In: Keio Journal of Medicine, Vol. 53, No. 4, 01.12.2004, p. 210-230.

Research output: Contribution to journalArticle

Horstman, Lawrence L. ; Jy, Wenche ; Jimenez, Joaquin J ; Bidot, Carlos ; Ahn, Yeon. / New horizons in the analysis of circulating cell-derived microparticles. In: Keio Journal of Medicine. 2004 ; Vol. 53, No. 4. pp. 210-230.
@article{914e3b1a61bd4c14a61b3577c5affa7b,
title = "New horizons in the analysis of circulating cell-derived microparticles",
abstract = "Analysis of circulating cell-derived microparticles (MP) is becoming more refined and clinically useful. This review, stemming from lectures given at Tokyo late 2003, does not repeat prior reviews but focusses on new horizons. A major theme is the rising recognition of platelets and their MP (PMP) as key mediators of inflammation/immunity. Among the major concepts developed are that (i) many so-called soluble markers of inflammation are in reality MP-bound; (ii) PMP and other MP appear to serve important signaling and immune functions including antigen presentation. In conclusion, MP analysis is poised to enter the mainstream of clinical testing, measuring specific antigens rather than gross levels. However, more research is needed to decisively establish their functions, and international standards are needed to allow comparing results from different laboratories.",
keywords = "Cell-derived microparticles, Inflammation, Platelet microparticles",
author = "Horstman, {Lawrence L.} and Wenche Jy and Jimenez, {Joaquin J} and Carlos Bidot and Yeon Ahn",
year = "2004",
month = "12",
day = "1",
doi = "10.2302/kjm.53.210",
language = "English",
volume = "53",
pages = "210--230",
journal = "Keio Journal of Medicine",
issn = "0022-9717",
publisher = "Keio University School of Medicine",
number = "4",

}

TY - JOUR

T1 - New horizons in the analysis of circulating cell-derived microparticles

AU - Horstman, Lawrence L.

AU - Jy, Wenche

AU - Jimenez, Joaquin J

AU - Bidot, Carlos

AU - Ahn, Yeon

PY - 2004/12/1

Y1 - 2004/12/1

N2 - Analysis of circulating cell-derived microparticles (MP) is becoming more refined and clinically useful. This review, stemming from lectures given at Tokyo late 2003, does not repeat prior reviews but focusses on new horizons. A major theme is the rising recognition of platelets and their MP (PMP) as key mediators of inflammation/immunity. Among the major concepts developed are that (i) many so-called soluble markers of inflammation are in reality MP-bound; (ii) PMP and other MP appear to serve important signaling and immune functions including antigen presentation. In conclusion, MP analysis is poised to enter the mainstream of clinical testing, measuring specific antigens rather than gross levels. However, more research is needed to decisively establish their functions, and international standards are needed to allow comparing results from different laboratories.

AB - Analysis of circulating cell-derived microparticles (MP) is becoming more refined and clinically useful. This review, stemming from lectures given at Tokyo late 2003, does not repeat prior reviews but focusses on new horizons. A major theme is the rising recognition of platelets and their MP (PMP) as key mediators of inflammation/immunity. Among the major concepts developed are that (i) many so-called soluble markers of inflammation are in reality MP-bound; (ii) PMP and other MP appear to serve important signaling and immune functions including antigen presentation. In conclusion, MP analysis is poised to enter the mainstream of clinical testing, measuring specific antigens rather than gross levels. However, more research is needed to decisively establish their functions, and international standards are needed to allow comparing results from different laboratories.

KW - Cell-derived microparticles

KW - Inflammation

KW - Platelet microparticles

UR - http://www.scopus.com/inward/record.url?scp=12344303983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12344303983&partnerID=8YFLogxK

U2 - 10.2302/kjm.53.210

DO - 10.2302/kjm.53.210

M3 - Article

C2 - 15647627

AN - SCOPUS:12344303983

VL - 53

SP - 210

EP - 230

JO - Keio Journal of Medicine

JF - Keio Journal of Medicine

SN - 0022-9717

IS - 4

ER -