New guidelines for topical NSAIDs in the osteoarthritis treatment paradigm

Roy D Altman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Osteoarthritis (OA), the most common form of arthritis, often affects hands, hips, and knees and involves an estimated 26.9 million US adults. Women have a higher prevalence of OA, and the risk of developing OA increases with age, obesity, and joint malalignment. OA typically presents with pain and reduced function. Therapeutic programs are often multimodal and must take into account pharmaceutical toxicities and patient comorbidities. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with cardiovascular, gastrointestinal, and renal adverse events. Topical NSAIDs offer efficacy with reduced systemic drug exposure. Research design and methods This is a review of current guideline recommendations regarding the use of topical NSAIDs in OA of the hand and knee. Articles were identified by PubMed search (January 1, 2000 to May 21, 2010). Results: Several current guidelines for management of OA recommend topical NSAIDs, indicating them as a safe and effective treatment. One guideline recommends that topical NSAIDs be considered as first-line pharmacologic therapy. A US guideline for knee OA recommends topical NSAIDs in older patients and in patients with increased gastrointestinal risk. Conclusions: The consensus across US and European OA guidelines is that topical NSAIDs are a safe and effective treatment for OA. Because the research base on topical NSAIDs for OA is small, guidelines will continue to evolve.

Original languageEnglish (US)
Pages (from-to)2871-2876
Number of pages6
JournalCurrent Medical Research and Opinion
Volume26
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

Fingerprint

Osteoarthritis
Anti-Inflammatory Agents
Guidelines
Pharmaceutical Preparations
Therapeutics
Knee Osteoarthritis
Hand
PubMed
Arthritis
Comorbidity
Hip
Knee
Consensus
Research Design
Obesity
Joints
Kidney
Pain
Research

Keywords

  • Guidelines
  • Hand osteoarthritis
  • Knee osteoarthritis
  • Nonsteroidal anti-inflammatory drugs
  • Topical administration

ASJC Scopus subject areas

  • Medicine(all)

Cite this

New guidelines for topical NSAIDs in the osteoarthritis treatment paradigm. / Altman, Roy D.

In: Current Medical Research and Opinion, Vol. 26, No. 12, 12.2010, p. 2871-2876.

Research output: Contribution to journalArticle

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