New frontiers in calvarial reconstruction: Integrating computer-assisted design and tissue engineering in cranioplasty

Harvey Chim, Jan Thorsten Schantz

Research output: Contribution to journalReview article

83 Scopus citations


Repair of large and complex calvarial defects remains a particular challenge for reconstruction. The paucity of techniques and materials emphasizes the need for alternative bone formation strategies. Recent integrative approaches suggest that successful reconstruction requires interdisciplinary teams, with surgeons interacting with imaging experts, materials scientists, and engineers. In this review, the authors present an overview of current materials used in calvarial reconstruction. Subsequently, progress in computer-designed prostheses, tissue engineering, and osteoinduction strategies is discussed. Finally, the authors discuss their experience with the integration of computer-aided fabrication of customized implants and tissue engineering for calvarial reconstruction.

Original languageEnglish (US)
Pages (from-to)1726-1741
Number of pages16
JournalPlastic and reconstructive surgery
Issue number6
StatePublished - Nov 1 2005


ASJC Scopus subject areas

  • Surgery

Cite this