Abstract
For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 140-143 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 52 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2016 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
Cite this
New formulation of old aspirin for better delivery. / Kalathil, Akil A.; Kumar, Anil; Banik, Bhabatosh; Ruiter, Timothy A.; Pathak, Rakesh K.; Dhar, Shanta.
In: Chemical Communications, Vol. 52, No. 1, 01.01.2016, p. 140-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - New formulation of old aspirin for better delivery
AU - Kalathil, Akil A.
AU - Kumar, Anil
AU - Banik, Bhabatosh
AU - Ruiter, Timothy A.
AU - Pathak, Rakesh K.
AU - Dhar, Shanta
PY - 2016/1/1
Y1 - 2016/1/1
N2 - For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.
AB - For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.
UR - http://www.scopus.com/inward/record.url?scp=84950245629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84950245629&partnerID=8YFLogxK
U2 - 10.1039/c5cc07316b
DO - 10.1039/c5cc07316b
M3 - Article
C2 - 26503669
AN - SCOPUS:84950245629
VL - 52
SP - 140
EP - 143
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 1
ER -