New formulation of old aspirin for better delivery

Akil A. Kalathil; Anil Kumar; Bhabatosh Banik; Timothy A. Ruiter; Rakesh K. Pathak; Shanta Dhar

doi:10.1039/c5cc07316b

New formulation of old aspirin for better delivery

Akil A. Kalathil, Anil Kumar, Bhabatosh Banik, Timothy A. Ruiter, Rakesh K. Pathak, Shanta Dhar

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.

Original language	English (US)
Pages (from-to)	140-143
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	1
DOIs	https://doi.org/10.1039/c5cc07316b
State	Published - 2016
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.",

author = "Kalathil, {Akil A.} and Anil Kumar and Bhabatosh Banik and Ruiter, {Timothy A.} and Pathak, {Rakesh K.} and Shanta Dhar",

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AU - Ruiter, Timothy A.

AU - Pathak, Rakesh K.

AU - Dhar, Shanta

PY - 2016

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AB - For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.

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New formulation of old aspirin for better delivery

Abstract

ASJC Scopus subject areas

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