New formulation of old aspirin for better delivery

Akil A. Kalathil; Anil Kumar; Bhabatosh Banik; Timothy A. Ruiter; Rakesh K. Pathak; Shanta Dhar

doi:10.1039/c5cc07316b

New formulation of old aspirin for better delivery

Akil A. Kalathil, Anil Kumar, Bhabatosh Banik, Timothy A. Ruiter, Rakesh K. Pathak, Shanta Dhar

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article

14 Scopus citations

Abstract

For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.

Original language	English (US)
Pages (from-to)	140-143
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	1
DOIs	https://doi.org/10.1039/c5cc07316b
State	Published - Jan 1 2016

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ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Cite this

Kalathil, A. A., Kumar, A., Banik, B., Ruiter, T. A., Pathak, R. K., & Dhar, S. (2016). New formulation of old aspirin for better delivery. Chemical Communications, 52(1), 140-143. https://doi.org/10.1039/c5cc07316b

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Access to Document

10.1039/c5cc07316b