New formulation of old aspirin for better delivery

Akil A. Kalathil, Anil Kumar, Bhabatosh Banik, Timothy A. Ruiter, Rakesh K. Pathak, Shanta Dhar

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.

Original languageEnglish (US)
Pages (from-to)140-143
Number of pages4
JournalChemical Communications
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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Aspirin
Anti-Inflammatory Agents
Nanoparticles
Prostaglandin-Endoperoxide Synthases
Cytokines

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Kalathil, A. A., Kumar, A., Banik, B., Ruiter, T. A., Pathak, R. K., & Dhar, S. (2016). New formulation of old aspirin for better delivery. Chemical Communications, 52(1), 140-143. https://doi.org/10.1039/c5cc07316b

New formulation of old aspirin for better delivery. / Kalathil, Akil A.; Kumar, Anil; Banik, Bhabatosh; Ruiter, Timothy A.; Pathak, Rakesh K.; Dhar, Shanta.

In: Chemical Communications, Vol. 52, No. 1, 01.01.2016, p. 140-143.

Research output: Contribution to journalArticle

Kalathil, AA, Kumar, A, Banik, B, Ruiter, TA, Pathak, RK & Dhar, S 2016, 'New formulation of old aspirin for better delivery', Chemical Communications, vol. 52, no. 1, pp. 140-143. https://doi.org/10.1039/c5cc07316b
Kalathil AA, Kumar A, Banik B, Ruiter TA, Pathak RK, Dhar S. New formulation of old aspirin for better delivery. Chemical Communications. 2016 Jan 1;52(1):140-143. https://doi.org/10.1039/c5cc07316b
Kalathil, Akil A. ; Kumar, Anil ; Banik, Bhabatosh ; Ruiter, Timothy A. ; Pathak, Rakesh K. ; Dhar, Shanta. / New formulation of old aspirin for better delivery. In: Chemical Communications. 2016 ; Vol. 52, No. 1. pp. 140-143.
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