New formulation of old aspirin for better delivery

Akil A. Kalathil, Anil Kumar, Bhabatosh Banik, Timothy A. Ruiter, Rakesh K. Pathak, Shanta Dhar

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

For better use of cyclooxygenase dependent anti-inflammatory properties and mitochondrial activities of aspirin, new hydrophobic analogues of aspirin were developed and successfully encapsulated in polymeric nanoparticles (NPs). In vivo anti-inflammatory effects of these NPs using a mouse model demonstrated unique properties of an optimized aspirin analogue to inhibit production of pro-inflammatory and enrichment of anti-inflammatory cytokines.

Original languageEnglish (US)
Pages (from-to)140-143
Number of pages4
JournalChemical Communications
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2016

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Kalathil, A. A., Kumar, A., Banik, B., Ruiter, T. A., Pathak, R. K., & Dhar, S. (2016). New formulation of old aspirin for better delivery. Chemical Communications, 52(1), 140-143. https://doi.org/10.1039/c5cc07316b