New Drugs and New Posterior Delivery Methods in CME

João Rafael de Oliveira Dias, Renata Portella Nunes, Raquel Goldhardt

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Purpose: The aim of this study is to discuss the characteristics, indications, and adverse events (AEs) of sustained-release corticosteroid devices for the treatment of cystoid macular edema (CME). Recent Findings: Ozurdex® is approved for the treatment of diabetic macular edema (DME), retinal vein occlusion-related CME, and noninfectious posterior uveitis (NIPU). It releases dexamethasone over a maximum period of 6 months making repeated intravitreal injections necessary for recurrent CME. Iluvien® releases fluocinolone for up to 36 months and is effective for the treatment of chronic DME. Retisert® (Bausch & Lomb, Rochester, NY, USA) also releases fluocinolone, and is approved for chronic NIPU. Both Iluvien® and Retisert® are non-biodegradable devices and are highly associated with cataract and glaucoma. Summary: Long-acting intraocular corticosteroid formulations offer a more predictable drug-release profile and reduced dosing frequency in comparison to conventional formulations of the same compounds but the risk-benefit ratio must be taken into consideration previous to the implantation of those devices.

Original languageEnglish (US)
Pages (from-to)160-168
Number of pages9
JournalCurrent Ophthalmology Reports
Volume5
Issue number2
DOIs
StatePublished - Jun 1 2017

Keywords

  • Cystoid macular edema
  • Dexamethasone intravitreal implant
  • Diabetic macular edema
  • Fluocinolone acetonide
  • Noninfectious posterior uveitis
  • Retinal vein occlusion

ASJC Scopus subject areas

  • Ophthalmology

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