TY - JOUR
T1 - New dendrimers containing a single cobaltocenium unit covalently attached to the apical position of Newkome dendrons
T2 - Electrochemistry and guest binding interactions with cucurbit[7]uril
AU - Sobransingh, David
AU - Kaifer, Angel E.
PY - 2006/12/5
Y1 - 2006/12/5
N2 - Two new dendrimer series were prepared and characterized. These dendrimers contain a single bis(cyclopentadienyl)-cobalt(III) (cobaltocenium, Cob +) unit covalently attached to the apical (focal) position of Newkome-type dendrons, ranging in size from first to third generation. The dendrimers in the first series (1ECob+ - 3ECob+) are hydrophobic and have 3, 9, and 27 tert-bulyl esters on their peripheries, whereas the dendrimers in the second series (1Cob+ - 3Cob +) are hydrophilic with 3, 9, and 27 carboxylic acid groups on their surfaces, respectively. In voltammetric experiments, all dendrimers showed the expected one-electron reversible reduction of the cobaltocenium center, and the heterogeneous rate of electron transfer decreased with generation in both dendrimer series. The host - guest binding interactions between water-soluble dendrimers 1Cob+ - 3Cob+ and the cucurbit[7]uril (CB7) host were investigated using 1H NMR spectroscopy, MALDI-TOF mass spectrometry, and electrochemical techniques. The association equilibrium constants (K) for all dendrimer guests were significantly lower than that measured for the inclusion complex between underivatized Cob+ and CB7 (K = 5.7 × 109 M-1)- Nonetheless, among the three dendrimers surveyed, the second-generation dendrimer, 2Cob+, afforded optimum stabilization for the CB7 inclusion complex.
AB - Two new dendrimer series were prepared and characterized. These dendrimers contain a single bis(cyclopentadienyl)-cobalt(III) (cobaltocenium, Cob +) unit covalently attached to the apical (focal) position of Newkome-type dendrons, ranging in size from first to third generation. The dendrimers in the first series (1ECob+ - 3ECob+) are hydrophobic and have 3, 9, and 27 tert-bulyl esters on their peripheries, whereas the dendrimers in the second series (1Cob+ - 3Cob +) are hydrophilic with 3, 9, and 27 carboxylic acid groups on their surfaces, respectively. In voltammetric experiments, all dendrimers showed the expected one-electron reversible reduction of the cobaltocenium center, and the heterogeneous rate of electron transfer decreased with generation in both dendrimer series. The host - guest binding interactions between water-soluble dendrimers 1Cob+ - 3Cob+ and the cucurbit[7]uril (CB7) host were investigated using 1H NMR spectroscopy, MALDI-TOF mass spectrometry, and electrochemical techniques. The association equilibrium constants (K) for all dendrimer guests were significantly lower than that measured for the inclusion complex between underivatized Cob+ and CB7 (K = 5.7 × 109 M-1)- Nonetheless, among the three dendrimers surveyed, the second-generation dendrimer, 2Cob+, afforded optimum stabilization for the CB7 inclusion complex.
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U2 - 10.1021/la061188o
DO - 10.1021/la061188o
M3 - Article
C2 - 17129028
AN - SCOPUS:33845994396
VL - 22
SP - 10540
EP - 10544
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 25
ER -