New Aspects in Descriptive, Etiologic, and Molecular Epidemiology of Hodgkin's Lymphoma

Ola Landgren, Neil E. Caporaso

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Epstein-Barr virus (EBV) has remained the main candidate suggested as the infection causing Hodgkin's lymphoma for several years. However, EBV genome has been found only within the tumor in about 20%-40% of Hodgkin's lymphoma cases with a prior diagnosis of infectious mononucleosis. Recently, autoimmune and related conditions have drawn attention to a potential role for immune-related and inflammatory conditions in the etiology and pathogenesis of the malignancy. Evidence from multiple affected families from case series, a twin study, a case-control study, and population-based registry studies implicate a role for genetic factors. Simultaneously, data from Eastern Asia and among Chinese immigrants in North America indicate increasing incidence trends for Hodgkin's lymphoma being associated with westernization. These results emphasize an interaction between environmental and genetic risk factors in Hodgkin's lymphoma.

Original languageEnglish (US)
Pages (from-to)825-840
Number of pages16
JournalHematology/Oncology Clinics of North America
Volume21
Issue number5
DOIs
StatePublished - Oct 2007
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology

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