La quimioterapia dirigida. nuevas modalidades para el tratamiento de varios cánceres con análogos cititóxicos de LH-RH, somatostatina y bombesina.

Translated title of the contribution: New approaches to treatment of various cancers based on cytotoxic analogs of LHRH, somatostatin and bombesin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The development of targeted cytotoxic analogs of hypothalamic peptides for the therapy of various cancers is reviewed and various oncological studies on experimental tumors are summarized. Novel therapeutic modalities for breast, prostate and ovarian cancer consist of the use of targeted cytotoxic analogs of LH-RH containing doxorubicin (DOX) or 2-pyrrolino-DOX. The same radicals have been incorporated finto cytotoxic analogs of somatostatin which can be also targeted to receptors for this peptide in prostatic, mammary, ovarian, renal cancers, brain tumors and their metastases, A targeted cytotoxic analog of bombesin containing 2-pyrrolino-DOX has been also synthesized and successfully tried in experimental models of prostate cancer, small cell lung carcinoma and brain tumors. The development of these new classes of peptide analogs should lead to a more effective treatment for various cancers.

Original languageSpanish
Pages (from-to)493-500
Number of pages8
JournalAnales de la Real Academia Nacional de Medicina
Volume121
Issue number3
StatePublished - Dec 1 2004
Externally publishedYes

Fingerprint

Bombesin
Somatostatin
Gonadotropin-Releasing Hormone
Brain Neoplasms
Doxorubicin
Ovarian Neoplasms
Prostatic Neoplasms
Neoplasms
Peptides
Peptide Receptors
Kidney Neoplasms
Small Cell Lung Carcinoma
Breast
Theoretical Models
Breast Neoplasms
Neoplasm Metastasis
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "The development of targeted cytotoxic analogs of hypothalamic peptides for the therapy of various cancers is reviewed and various oncological studies on experimental tumors are summarized. Novel therapeutic modalities for breast, prostate and ovarian cancer consist of the use of targeted cytotoxic analogs of LH-RH containing doxorubicin (DOX) or 2-pyrrolino-DOX. The same radicals have been incorporated finto cytotoxic analogs of somatostatin which can be also targeted to receptors for this peptide in prostatic, mammary, ovarian, renal cancers, brain tumors and their metastases, A targeted cytotoxic analog of bombesin containing 2-pyrrolino-DOX has been also synthesized and successfully tried in experimental models of prostate cancer, small cell lung carcinoma and brain tumors. The development of these new classes of peptide analogs should lead to a more effective treatment for various cancers.",
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