New approaches to treatment of various cancers based on cytotoxic analogs of LHRH, somatostatin and bombesin

Andrew V. Schally, Attila Nagy

Research output: Contribution to journalShort survey

119 Scopus citations

Abstract

The development of targeted cytotoxic analogs of hypothalamic peptides for the therapy of various cancers is reviewed and various oncological studies on experimental tumors are summarized. Novel therapeutic modalities for breast, prostate and ovarian cancer consist of the use of targeted cytotoxic analogs of LH-RH containing doxorubicin (DOX) or 2-pyrrolino-DOX. The same radicals have been incorporated into cytotoxic analogs of somatostatin which can be also targeted to receptors for this peptide in prostatic, mammary, ovarian, renal and lung cancers, brain tumors and their metastases. A targeted cytotoxic analog of bombesin containing 2-pyrrolino-DOX has also been synthesized and successfully tried in experimental models of prostate cancer, small cell lung carcinoma and brain tumors. The development of these new classes of peptide analogs should lead to a more effective treatment for various cancers.

Original languageEnglish (US)
Pages (from-to)2305-2320
Number of pages16
JournalLife Sciences
Volume72
Issue number21
DOIs
StatePublished - Apr 11 2003
Externally publishedYes

Keywords

  • Breast cancer therapy
  • Lung cancer therapy
  • Ovarian cancer therapy
  • Prostate cancer therapy
  • Renal cancer therapy
  • Targeted cytotoxic analogs

ASJC Scopus subject areas

  • Pharmacology

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