New analgesic drugs derived from phencyclidine

Yossef Itzhak, Asher Kalir, Ben Avi Weissman, Sasson Cohen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Several esters of 1-(1-phenylcyclohexyl)-4-piperidinol (3), 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol (10) and its propionate (11), and 1-(1-phenylcyclohexyl)-4-phenylpiperidine (13) were prepared and characterized. The new compounds, which are derived from phencyclidine, exerted analgesic activity in mice. The most potent is 10, which is twice as active as morphine. The antinociceptive activity of 10, 11, and 13 could be well correlated with their potency in the mouse vas deferens bioassay, and both were completely reversed by naloxone.

Original languageEnglish
Pages (from-to)496-499
Number of pages4
JournalJournal of Medicinal Chemistry
Volume24
Issue number5
StatePublished - Dec 1 1981
Externally publishedYes

Fingerprint

Phencyclidine
Bioassay
Propionates
Naloxone
Morphine
Analgesics
Esters
Vas Deferens
Biological Assay
4-phenylpiperidine
1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Itzhak, Y., Kalir, A., Weissman, B. A., & Cohen, S. (1981). New analgesic drugs derived from phencyclidine. Journal of Medicinal Chemistry, 24(5), 496-499.

New analgesic drugs derived from phencyclidine. / Itzhak, Yossef; Kalir, Asher; Weissman, Ben Avi; Cohen, Sasson.

In: Journal of Medicinal Chemistry, Vol. 24, No. 5, 01.12.1981, p. 496-499.

Research output: Contribution to journalArticle

Itzhak, Y, Kalir, A, Weissman, BA & Cohen, S 1981, 'New analgesic drugs derived from phencyclidine', Journal of Medicinal Chemistry, vol. 24, no. 5, pp. 496-499.
Itzhak Y, Kalir A, Weissman BA, Cohen S. New analgesic drugs derived from phencyclidine. Journal of Medicinal Chemistry. 1981 Dec 1;24(5):496-499.
Itzhak, Yossef ; Kalir, Asher ; Weissman, Ben Avi ; Cohen, Sasson. / New analgesic drugs derived from phencyclidine. In: Journal of Medicinal Chemistry. 1981 ; Vol. 24, No. 5. pp. 496-499.
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