New Analgesic Drugs Derived from Phencyclidine

Yossef Itzhak, Asher Kalir, Ben Avi Weissman, Sasson Cohen

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Several esters of 1-(1-phenylcyclohexyl)-4-piperidinol (3), 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol (10) and its propionate (11), and 1-(1-phenylcyclohexyl)-4-phenylpiperidine (13) were prepared and characterized. The new compounds, which are derived from phencyclidine, exerted analgesic activity in mice. The most potent is 10, which is twice as active as morphine. The antinociceptive activity of 10, 11, and 13 could be well correlated with their potency in the mouse vas deferens bioassay, and both were completely reversed by naloxone.

Original languageEnglish (US)
Pages (from-to)496-499
Number of pages4
JournalJournal of Medicinal Chemistry
Volume24
Issue number5
DOIs
StatePublished - May 1981

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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