New advances in CMV and immunosenescence

Paolo Sansoni, Rosanna Vescovini, Francesco F. Fagnoni, Arne Akbar, Ramon Arens, Yen Ling Chiu, Luka Čičin-Šain, Julie Dechanet-Merville, Evelyna Derhovanessian, Sara Ferrando-Martinez, Claudio Franceschi, Daniela Frasca, Tamas Fulöp, David Furman, Effrossyni Gkrania-Klotsas, Felicia Goodrum, Beatrix Grubeck-Loebenstein, Mikko Hurme, Florian Kern, Daniele LilleriMiguel López-Botet, Andrea B. Maier, Thomas Marandu, Arnaud Marchant, Catharina Matheï, Paul Moss, Aura Muntasell, Ester B.M. Remmerswaal, Natalie E. Riddell, Kathrin Rothe, Delphine Sauce, Eui Cheol Shin, Amanda M. Simanek, Megan J. Smithey, Cecilia Söderberg-Nauclér, Rafael Solana, Paul G. Thomas, Rene Van Lier, Graham Pawelec, Janko Nikolich-Zugich

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.

Original languageEnglish (US)
Pages (from-to)54-62
Number of pages9
JournalExperimental Gerontology
Volume55
DOIs
StatePublished - Jul 2014

Keywords

  • Cytomegalovirus infection
  • Immune homeostasis
  • Immunosenescence
  • Pathologies of aging
  • Virus-host interaction

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Cell Biology
  • Endocrinology
  • Genetics
  • Molecular Biology

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    Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y. L., Čičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando-Martinez, S., Franceschi, C., Frasca, D., Fulöp, T., Furman, D., Gkrania-Klotsas, E., Goodrum, F., Grubeck-Loebenstein, B., Hurme, M., Kern, F., ... Nikolich-Zugich, J. (2014). New advances in CMV and immunosenescence. Experimental Gerontology, 55, 54-62. https://doi.org/10.1016/j.exger.2014.03.020