Abstract
This prospective study compares levels of neutrophil chemotactic activity (NCA) in gastric juice to the neutrophil count in gastric biopsies. Sixty-three male patients enrolled in the study and had antral biopsies following collection of gastric juice during esophagogastroduodenoscopy. Biopsies were examined for the magnitude of gastritis, tissue PMN count, and presence of Helicobacter pylori. Secretions were assayed for neutrophil chemotactic activity. Results show an increase in NCA and in tissue PMN counts with increasing severity of gastritis. H. pylori-positive patients had higher levels of NCA and PMN than H. pylori-negative patients. Wide variability in NCA levels preclude a direct correlation between NCA and PMN counts.
| Original language | English |
|---|---|
| Pages (from-to) | 1277-1280 |
| Number of pages | 4 |
| Journal | Digestive Diseases and Sciences |
| Volume | 36 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 1991 |
| Externally published | Yes |
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Keywords
- gastric mucosa
- gastritis
- Helicobacter pylori
- inflammatory mediators
- neutrophil chemotactic factors
- neutrophils
ASJC Scopus subject areas
- Gastroenterology
Cite this
Neutrophil chemotaxis in gastric mucosa - A signal-to-response comparison. / Kozol, Robert; Domanowski, A.; Jaszewski, R.; Czanko, R.; McCurdy, B.; Prasad, M.; Fromm, B.; Calzada, R.
In: Digestive Diseases and Sciences, Vol. 36, No. 9, 01.09.1991, p. 1277-1280.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neutrophil chemotaxis in gastric mucosa - A signal-to-response comparison
AU - Kozol, Robert
AU - Domanowski, A.
AU - Jaszewski, R.
AU - Czanko, R.
AU - McCurdy, B.
AU - Prasad, M.
AU - Fromm, B.
AU - Calzada, R.
PY - 1991/9/1
Y1 - 1991/9/1
N2 - This prospective study compares levels of neutrophil chemotactic activity (NCA) in gastric juice to the neutrophil count in gastric biopsies. Sixty-three male patients enrolled in the study and had antral biopsies following collection of gastric juice during esophagogastroduodenoscopy. Biopsies were examined for the magnitude of gastritis, tissue PMN count, and presence of Helicobacter pylori. Secretions were assayed for neutrophil chemotactic activity. Results show an increase in NCA and in tissue PMN counts with increasing severity of gastritis. H. pylori-positive patients had higher levels of NCA and PMN than H. pylori-negative patients. Wide variability in NCA levels preclude a direct correlation between NCA and PMN counts.
AB - This prospective study compares levels of neutrophil chemotactic activity (NCA) in gastric juice to the neutrophil count in gastric biopsies. Sixty-three male patients enrolled in the study and had antral biopsies following collection of gastric juice during esophagogastroduodenoscopy. Biopsies were examined for the magnitude of gastritis, tissue PMN count, and presence of Helicobacter pylori. Secretions were assayed for neutrophil chemotactic activity. Results show an increase in NCA and in tissue PMN counts with increasing severity of gastritis. H. pylori-positive patients had higher levels of NCA and PMN than H. pylori-negative patients. Wide variability in NCA levels preclude a direct correlation between NCA and PMN counts.
KW - gastric mucosa
KW - gastritis
KW - Helicobacter pylori
KW - inflammatory mediators
KW - neutrophil chemotactic factors
KW - neutrophils
UR - http://www.scopus.com/inward/record.url?scp=0025866109&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025866109&partnerID=8YFLogxK
U2 - 10.1007/BF01307522
DO - 10.1007/BF01307522
M3 - Article
VL - 36
SP - 1277
EP - 1280
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 9
ER -