Neutrophil chemotaxis in gastric mucosa - A signal-to-response comparison

R. Kozol; A. Domanowski; R. Jaszewski; R. Czanko; B. McCurdy; M. Prasad; B. Fromm; R. Calzada

doi:10.1007/BF01307522

Neutrophil chemotaxis in gastric mucosa - A signal-to-response comparison

R. Kozol, A. Domanowski, R. Jaszewski, R. Czanko, B. McCurdy, M. Prasad, B. Fromm, R. Calzada

Surgery

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

This prospective study compares levels of neutrophil chemotactic activity (NCA) in gastric juice to the neutrophil count in gastric biopsies. Sixty-three male patients enrolled in the study and had antral biopsies following collection of gastric juice during esophagogastroduodenoscopy. Biopsies were examined for the magnitude of gastritis, tissue PMN count, and presence of Helicobacter pylori. Secretions were assayed for neutrophil chemotactic activity. Results show an increase in NCA and in tissue PMN counts with increasing severity of gastritis. H. pylori-positive patients had higher levels of NCA and PMN than H. pylori-negative patients. Wide variability in NCA levels preclude a direct correlation between NCA and PMN counts.

Original language	English (US)
Pages (from-to)	1277-1280
Number of pages	4
Journal	Digestive Diseases and Sciences
Volume	36
Issue number	9
DOIs	https://doi.org/10.1007/BF01307522
State	Published - Sep 1 1991

Keywords

gastric mucosa
gastritis
Helicobacter pylori
inflammatory mediators
neutrophil chemotactic factors
neutrophils

ASJC Scopus subject areas

Gastroenterology

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10.1007/BF01307522

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title = "Neutrophil chemotaxis in gastric mucosa - A signal-to-response comparison",

abstract = "This prospective study compares levels of neutrophil chemotactic activity (NCA) in gastric juice to the neutrophil count in gastric biopsies. Sixty-three male patients enrolled in the study and had antral biopsies following collection of gastric juice during esophagogastroduodenoscopy. Biopsies were examined for the magnitude of gastritis, tissue PMN count, and presence of Helicobacter pylori. Secretions were assayed for neutrophil chemotactic activity. Results show an increase in NCA and in tissue PMN counts with increasing severity of gastritis. H. pylori-positive patients had higher levels of NCA and PMN than H. pylori-negative patients. Wide variability in NCA levels preclude a direct correlation between NCA and PMN counts.",

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AU - Prasad, M.

AU - Fromm, B.

AU - Calzada, R.

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