Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with non-small-cell lung cancer: Case report and review of literature

Gina D'Amato, Caio Rocha Lima, J. J. Mahany, Carlos Muro-Cacho, Eric B. Haura

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Neutropenic enterocolitis (NE) is an unusual acute complication of neutropenia, most often associated with leukemia and lymphoma which is characterized by segmental cecal and ascending colon ulceration that may progress to necrosis, perforation, and septicemia. We present a case of neutropenic enterocolitis in a patient with non-small-cell lung cancer who received docetaxel and flavopiridol as part of a phase I clinical trial and review cases in the literature where docetaxel was involved. Given the increased use of docetaxel and other taxanes in the treatment of advanced lung cancer, physicians should be aware of this potential toxicity of therapy.

Original languageEnglish
Pages (from-to)381-390
Number of pages10
JournalLung Cancer
Volume44
Issue number3
DOIs
StatePublished - Jun 1 2004

Fingerprint

docetaxel
Neutropenic Enterocolitis
Non-Small Cell Lung Carcinoma
alvocidib
Ascending Colon
Taxoids
Clinical Trials, Phase I
Neutropenia
Lymphoma
Lung Neoplasms
Sepsis
Leukemia
Necrosis
Therapeutics
Physicians

Keywords

  • Chemotherapy
  • Lung cancer
  • Neutropenic enterocolitis
  • Taxanes
  • Typhlitis

ASJC Scopus subject areas

  • Oncology

Cite this

Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with non-small-cell lung cancer : Case report and review of literature. / D'Amato, Gina; Lima, Caio Rocha; Mahany, J. J.; Muro-Cacho, Carlos; Haura, Eric B.

In: Lung Cancer, Vol. 44, No. 3, 01.06.2004, p. 381-390.

Research output: Contribution to journalArticle

D'Amato, Gina ; Lima, Caio Rocha ; Mahany, J. J. ; Muro-Cacho, Carlos ; Haura, Eric B. / Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with non-small-cell lung cancer : Case report and review of literature. In: Lung Cancer. 2004 ; Vol. 44, No. 3. pp. 381-390.
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