Neurovisceral integration in the executive control network: A resting state analysis

Roger C. McIntosh, Rosangela Hoshi, Jason S. Nomi, Maria Di Bello, Zachary T. Goodman, Salome Kornfeld, Lucina Q. Uddin, Cristina Ottaviani

Research output: Contribution to journalArticlepeer-review

Abstract

Neurovisceral integration models emphasize the role of frontal lobes in cognitive, behavioral, and emotional regulation. Two candidate hubs for the regulation of cardio-autonomic control, anxiety, and executive attention are the dorsolateral prefrontal cortex (DLPFC) and middle frontal gyrus (MFG). Two-hundred and seventy-one adults (62.9 % female) aged 18–85 years were selected from the NKI-Rockland Sample. Resting state functional imaging data was preprocessed, and seeds extracted from bilateral DLPFC and MFG to test 4 regression models predicting connectivity with high frequency HRV (HF-HRV), trait anxiety (TA), and reaction time on an executive attention task. After controlling for age, sex, body mass index and head motion, the right DLPFC-MFG seed pair provided strongest support for neurovisceral integration indexed by HF-HRV, low TA and shorter reaction time on the attention network task. This hemispheric effect may underlie the inhibitory role of right PFC in the regulation of cardio-autonomic function, emotion, and executive attention.

Original languageEnglish (US)
Article number107986
JournalBiological Psychology
Volume157
DOIs
StatePublished - Nov 2020

Keywords

  • Attention network task
  • Executive control network
  • Resting state functional magnetic resonance imaging
  • Seed connectivity
  • Vagal

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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