TY - JOUR
T1 - Neurotrophins in skin biology and pathology
AU - Botchkarev, Vladimir A.
AU - Yaar, Mina
AU - Peters, Eva M.J.
AU - Raychaudhuri, Siba P.
AU - Botchkareva, Natalia V.
AU - Marconi, Alessandra
AU - Raychaudhuri, Smriti K.
AU - Paus, Ralf
AU - Pincelli, Carlo
N1 - Funding Information:
Work on this review was supported in part by grants from the National Alopecia Areata Foundation and North-American Hair Research Society to V.A.B. Owing to the space limitations, authors were not able to cite many original publications on different aspects of NT signalling and would like to address readers to the corresponding review articles.
PY - 2006/8
Y1 - 2006/8
N2 - Neurotrophins (NTs) belong to a family of growth factors, which control the development, maintenance, and apoptotic death of neurons and also fulfill multiple regulatory functions outside the nervous system. Biological effects induced by NTs strongly depend on the pattern of NT receptor/co-receptors expression in target cells, as well as on the set of intracellular adaptor molecules that link NT signalling to distinct biochemical pathways. In this review, we summarize data on the molecular mechanisms underlying the involvement of NTs in the control of non-neuronal functions in normal skin (e.g. keratinocyte proliferation, melanocyte development and apoptosis, hair growth). We also review the data on the role for NTs and their receptors in a number of pathological skin conditions (stress-induced hair loss, psoriasis, atopic dermatitis). Although additional efforts are required to fully understand mechanisms underlying the involvement of NTs and their receptors in controlling functions of normal and pathologically altered skin cells, substantial evidence suggests that modulation of NT signalling by NTs receptor agonists/antagonists may be developed as intervention modalities in distinct skin and hair growth pathologies.
AB - Neurotrophins (NTs) belong to a family of growth factors, which control the development, maintenance, and apoptotic death of neurons and also fulfill multiple regulatory functions outside the nervous system. Biological effects induced by NTs strongly depend on the pattern of NT receptor/co-receptors expression in target cells, as well as on the set of intracellular adaptor molecules that link NT signalling to distinct biochemical pathways. In this review, we summarize data on the molecular mechanisms underlying the involvement of NTs in the control of non-neuronal functions in normal skin (e.g. keratinocyte proliferation, melanocyte development and apoptosis, hair growth). We also review the data on the role for NTs and their receptors in a number of pathological skin conditions (stress-induced hair loss, psoriasis, atopic dermatitis). Although additional efforts are required to fully understand mechanisms underlying the involvement of NTs and their receptors in controlling functions of normal and pathologically altered skin cells, substantial evidence suggests that modulation of NT signalling by NTs receptor agonists/antagonists may be developed as intervention modalities in distinct skin and hair growth pathologies.
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U2 - 10.1038/sj.jid.5700270
DO - 10.1038/sj.jid.5700270
M3 - Article
C2 - 16845411
AN - SCOPUS:33746148923
VL - 126
SP - 1719
EP - 1727
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 8
ER -