Neurotrophins affect survival and neuritogenesis by adult injured auditory neurons in vitro

Philippe P. Lefebvre, Brigitte Malgrange, Hinrich Staecker, Masseih Moghadass, Thomas R. Van De Water, Gustave Moonen

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

This study evaluates the trophic effects of three neurotrophins on traumatized adult auditory neurons in culture, and the presence of these neurotrophins in cochlear nucleus tissue. BDNF and NT-3 promoted survival but very limited neuritogenesis by adult auditory neurons in vitro, while NGF, although without a survival effect, evoked a robust neuritic outgrowth response when combined with BDNF. Messenger RNAs that encode for NGF, BDNF and NT-3 were detected by RT-PCR in RNA extracts from adult cochlear nuclei tissue. Based on these in vitro and in vivo findings, we propose NT-3 as the agent of the peripheral target-derived survival promoting effect and NGF, BDNF, and NT-3 as mediators of trophic influences originating from the central target (i.e. cochlear nucleus).

Original languageEnglish (US)
Pages (from-to)865-868
Number of pages4
JournalNeuroreport
Volume5
Issue number8
DOIs
StatePublished - Apr 1994

Keywords

  • brain derived neurotrophic factor
  • cochlea
  • nerve growth factor
  • neurotrophin-3
  • regeneration

ASJC Scopus subject areas

  • Neuroscience(all)

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    Lefebvre, P. P., Malgrange, B., Staecker, H., Moghadass, M., Van De Water, T. R., & Moonen, G. (1994). Neurotrophins affect survival and neuritogenesis by adult injured auditory neurons in vitro. Neuroreport, 5(8), 865-868. https://doi.org/10.1097/00001756-199404000-00003