Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis

Vladimir A. Botchkarev, Natalia V. Botchkareva, Kathryn M. Albers, Carina Van Der Veen, Gary R. Lewin, Ralf Paus

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Hair follicle epithelium and nervous system share a common ectodermal origin, and some neurotrophins can modulate keratinocyte proliferation and apoptosis. It is therefore reasonable to ask whether growth factors that control neural development are also involved in the regulation of hair follicle morphogenesis. Focusing on neurotrophin-3 (NT-3) and its high- affinity-receptor [tyrosine kinase C (TrkC)], we show that hair placode keratinocytes express TrkC mRNA and immunoreactivity early during murine hair folicle morphogenesis. In later stages of hair follicle development, TrkC mRNA, TrkC-, and NT-3-immunoreactivity are seen in keratinocytes of the proximal hair bulb as well as in dermal papilla fibroblasts. Compared with the corresponding wild-type animals, early stages of hair follicle morphogenesis are significantly accelerated in newborn NT-3 overexpressing mice, whereas these are retarded in newborn heterozygous NT-3 knockout (+/-) mice. These observations suggest that NT-3 is an important growth modulator during morphogenesis and remodeling of neuroectodermal-mesenchymal interaction systems like the hair follicle.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalJournal of Investigative Dermatology
Issue number2
StatePublished - 1998
Externally publishedYes


  • Development
  • NT-3
  • Skin
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


Dive into the research topics of 'Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis'. Together they form a unique fingerprint.

Cite this