Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis

Vladimir A. Botchkarev, Natalia V. Botchkareva, Kathryn M. Albers, Carina Van Der Veen, Gary R. Lewin, Ralf Paus

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Hair follicle epithelium and nervous system share a common ectodermal origin, and some neurotrophins can modulate keratinocyte proliferation and apoptosis. It is therefore reasonable to ask whether growth factors that control neural development are also involved in the regulation of hair follicle morphogenesis. Focusing on neurotrophin-3 (NT-3) and its high- affinity-receptor [tyrosine kinase C (TrkC)], we show that hair placode keratinocytes express TrkC mRNA and immunoreactivity early during murine hair folicle morphogenesis. In later stages of hair follicle development, TrkC mRNA, TrkC-, and NT-3-immunoreactivity are seen in keratinocytes of the proximal hair bulb as well as in dermal papilla fibroblasts. Compared with the corresponding wild-type animals, early stages of hair follicle morphogenesis are significantly accelerated in newborn NT-3 overexpressing mice, whereas these are retarded in newborn heterozygous NT-3 knockout (+/-) mice. These observations suggest that NT-3 is an important growth modulator during morphogenesis and remodeling of neuroectodermal-mesenchymal interaction systems like the hair follicle.

Original languageEnglish (US)
Pages (from-to)279-285
Number of pages7
JournalJournal of Investigative Dermatology
Volume111
Issue number2
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

Neurotrophin 3
Hair Follicle
Morphogenesis
Keratinocytes
Protein-Tyrosine Kinases
Hair
Messenger RNA
Wild Animals
Nerve Growth Factors
Receptor Protein-Tyrosine Kinases
Neurology
Fibroblasts
Knockout Mice
Nervous System
Modulators
Intercellular Signaling Peptides and Proteins
Animals
Epithelium
Apoptosis
Skin

Keywords

  • Development
  • NT-3
  • Skin
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Botchkarev, V. A., Botchkareva, N. V., Albers, K. M., Van Der Veen, C., Lewin, G. R., & Paus, R. (1998). Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis. Journal of Investigative Dermatology, 111(2), 279-285. https://doi.org/10.1046/j.1523-1747.1998.00277.x

Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis. / Botchkarev, Vladimir A.; Botchkareva, Natalia V.; Albers, Kathryn M.; Van Der Veen, Carina; Lewin, Gary R.; Paus, Ralf.

In: Journal of Investigative Dermatology, Vol. 111, No. 2, 01.01.1998, p. 279-285.

Research output: Contribution to journalArticle

Botchkarev, VA, Botchkareva, NV, Albers, KM, Van Der Veen, C, Lewin, GR & Paus, R 1998, 'Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis', Journal of Investigative Dermatology, vol. 111, no. 2, pp. 279-285. https://doi.org/10.1046/j.1523-1747.1998.00277.x
Botchkarev, Vladimir A. ; Botchkareva, Natalia V. ; Albers, Kathryn M. ; Van Der Veen, Carina ; Lewin, Gary R. ; Paus, Ralf. / Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis. In: Journal of Investigative Dermatology. 1998 ; Vol. 111, No. 2. pp. 279-285.
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