Abstract
Hair follicle epithelium and nervous system share a common ectodermal origin, and some neurotrophins can modulate keratinocyte proliferation and apoptosis. It is therefore reasonable to ask whether growth factors that control neural development are also involved in the regulation of hair follicle morphogenesis. Focusing on neurotrophin-3 (NT-3) and its high- affinity-receptor [tyrosine kinase C (TrkC)], we show that hair placode keratinocytes express TrkC mRNA and immunoreactivity early during murine hair folicle morphogenesis. In later stages of hair follicle development, TrkC mRNA, TrkC-, and NT-3-immunoreactivity are seen in keratinocytes of the proximal hair bulb as well as in dermal papilla fibroblasts. Compared with the corresponding wild-type animals, early stages of hair follicle morphogenesis are significantly accelerated in newborn NT-3 overexpressing mice, whereas these are retarded in newborn heterozygous NT-3 knockout (+/-) mice. These observations suggest that NT-3 is an important growth modulator during morphogenesis and remodeling of neuroectodermal-mesenchymal interaction systems like the hair follicle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 279-285 |
| Number of pages | 7 |
| Journal | Journal of Investigative Dermatology |
| Volume | 111 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1998 |
| Externally published | Yes |
Fingerprint
Keywords
- Development
- NT-3
- Skin
- Tyrosine kinase
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology
- Cell Biology
Cite this
Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis. / Botchkarev, Vladimir A.; Botchkareva, Natalia V.; Albers, Kathryn M.; Van Der Veen, Carina; Lewin, Gary R.; Paus, Ralf.
In: Journal of Investigative Dermatology, Vol. 111, No. 2, 01.01.1998, p. 279-285.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis
AU - Botchkarev, Vladimir A.
AU - Botchkareva, Natalia V.
AU - Albers, Kathryn M.
AU - Van Der Veen, Carina
AU - Lewin, Gary R.
AU - Paus, Ralf
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Hair follicle epithelium and nervous system share a common ectodermal origin, and some neurotrophins can modulate keratinocyte proliferation and apoptosis. It is therefore reasonable to ask whether growth factors that control neural development are also involved in the regulation of hair follicle morphogenesis. Focusing on neurotrophin-3 (NT-3) and its high- affinity-receptor [tyrosine kinase C (TrkC)], we show that hair placode keratinocytes express TrkC mRNA and immunoreactivity early during murine hair folicle morphogenesis. In later stages of hair follicle development, TrkC mRNA, TrkC-, and NT-3-immunoreactivity are seen in keratinocytes of the proximal hair bulb as well as in dermal papilla fibroblasts. Compared with the corresponding wild-type animals, early stages of hair follicle morphogenesis are significantly accelerated in newborn NT-3 overexpressing mice, whereas these are retarded in newborn heterozygous NT-3 knockout (+/-) mice. These observations suggest that NT-3 is an important growth modulator during morphogenesis and remodeling of neuroectodermal-mesenchymal interaction systems like the hair follicle.
AB - Hair follicle epithelium and nervous system share a common ectodermal origin, and some neurotrophins can modulate keratinocyte proliferation and apoptosis. It is therefore reasonable to ask whether growth factors that control neural development are also involved in the regulation of hair follicle morphogenesis. Focusing on neurotrophin-3 (NT-3) and its high- affinity-receptor [tyrosine kinase C (TrkC)], we show that hair placode keratinocytes express TrkC mRNA and immunoreactivity early during murine hair folicle morphogenesis. In later stages of hair follicle development, TrkC mRNA, TrkC-, and NT-3-immunoreactivity are seen in keratinocytes of the proximal hair bulb as well as in dermal papilla fibroblasts. Compared with the corresponding wild-type animals, early stages of hair follicle morphogenesis are significantly accelerated in newborn NT-3 overexpressing mice, whereas these are retarded in newborn heterozygous NT-3 knockout (+/-) mice. These observations suggest that NT-3 is an important growth modulator during morphogenesis and remodeling of neuroectodermal-mesenchymal interaction systems like the hair follicle.
KW - Development
KW - NT-3
KW - Skin
KW - Tyrosine kinase
UR - http://www.scopus.com/inward/record.url?scp=0031928723&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031928723&partnerID=8YFLogxK
U2 - 10.1046/j.1523-1747.1998.00277.x
DO - 10.1046/j.1523-1747.1998.00277.x
M3 - Article
C2 - 9699730
AN - SCOPUS:0031928723
VL - 111
SP - 279
EP - 285
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 2
ER -