TY - JOUR
T1 - Neurotransmitters act as paracrine signals to regulate insulin secretion from the human pancreatic islet
AU - Rodriguez-Diaz, Rayner
AU - Menegaz, Danusa
AU - Caicedo, Alejandro
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/8/15
Y1 - 2014/8/15
N2 - In this symposium review we discuss the role of neurotransmitters as paracrine signals that regulate pancreatic islet function. A large number of neurotransmitters and their receptors has been identified in the islet, but relatively little is known about their involvement in islet biology. Interestingly, neurotransmitters initially thought to be present in autonomic axons innervating the islet are also present in endocrine cells of the human islet. These neurotransmitters can thus be released as paracrine signals to help control hormone release. Here we propose that the role of neurotransmitters may extend beyond controlling endocrine cell function to work as signals modulating vascular flow and immune responses within the islet.
AB - In this symposium review we discuss the role of neurotransmitters as paracrine signals that regulate pancreatic islet function. A large number of neurotransmitters and their receptors has been identified in the islet, but relatively little is known about their involvement in islet biology. Interestingly, neurotransmitters initially thought to be present in autonomic axons innervating the islet are also present in endocrine cells of the human islet. These neurotransmitters can thus be released as paracrine signals to help control hormone release. Here we propose that the role of neurotransmitters may extend beyond controlling endocrine cell function to work as signals modulating vascular flow and immune responses within the islet.
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U2 - 10.1113/jphysiol.2013.269910
DO - 10.1113/jphysiol.2013.269910
M3 - Article
C2 - 24591573
AN - SCOPUS:84906096417
VL - 592
SP - 3413
EP - 3417
JO - Journal of Physiology
JF - Journal of Physiology
SN - 0022-3751
IS - 16
ER -