Neurotransmitter regulation of CRF secretion in vitro

Michael J. Owens, Charles B. Nemeroff

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A decade prior to elucidation of the sequence of corticotropin-releasing factor (CRF), investigators were already studying the neurotransmitter regulation of CRF release in vitro using bioassays for ACTH and adrenal glucocorticoids as a measure of “CRF” activity. Even with the availability of sensitive and specific radioimmunoassays for CRF, considerable controversy exists concerning the role of various neurotransmitters in regulating the secretion of hypothalamic CRF.

Original languageEnglish (US)
Title of host publicationCorticotropin-Releasing Factor
Subtitle of host publicationBasic and Clinical Studies of a Neuropeptide
PublisherCRC Press
Pages107-113
Number of pages7
ISBN (Electronic)9781351079389
ISBN (Print)0849345502, 9781315891835
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Owens, M. J., & Nemeroff, C. B. (2018). Neurotransmitter regulation of CRF secretion in vitro. In Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide (pp. 107-113). CRC Press. https://doi.org/10.1201/9781351070935