Neurotoxicities in infants seen with the consumption of star anise tea

Diego Ize-Ludlow, Sean Ragone, Isaac S. Bruck, Jeffrey N. Bernstein, Michael Duchowny, B. M. Garcia Peña

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Chinese star anise (Illicium verum Hook f.) is a well-known spice used in many cultures. Many populations use it as a treatment for infant colic. Japanese star anise (Illicium anisatum L), however, has been documented to have both neurologic and gastrointestinal toxicities. Recently, concern has been raised regarding the adulteration of Chinese star anise with Japanese star anise. We report 7 cases of adverse neurologic reactions in infants seen with the home administration of star anise tea. In addition, we have found evidence that Chinese star anise has been contaminated with Japanese star anise. More strict federal regulation of the import of star anise into the United States is warranted. Star anise tea should no longer be administered to infants because of its potential danger in this population.

Original languageEnglish (US)
Pages (from-to)e653-e656
Issue number5
StatePublished - Nov 2004
Externally publishedYes


  • Colic
  • Infants
  • Neurotoxicity
  • Star anise

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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