Neurotoxic shellfish poisoning

Sharon M. Watkins, Andrew Reich, Lora E. Fleming, Roberta Hammond

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Neurotoxic shellfish poisoning (NSP) is caused by consumption of molluscan shellfish contaminated with brevetoxins primarily produced by the dinoflagellate, Karenia brevis. Blooms of K. brevis, called Florida red tide, occur frequently along the Gulf of Mexico. Many shellfish beds in the US (and other nations) are routinely monitored for presence of K. brevis and other brevetoxin-producing organisms. As a result, few NSP cases are reported annually from the US. However, infrequent larger outbreaks do occur. Cases are usually associated with recreationally-harvested shellfish collected during or post red tide blooms. Brevetoxins are neurotoxins which activate voltage-sensitive sodium channels causing sodium influx and nerve membrane depolarization. No fatalities have been reported, but hospitalizations occur. NSP involves a cluster of gastrointestinal and neurological symptoms: nausea and vomiting, paresthesias of the mouth, lips and tongue as well as distal paresthesias, ataxia, slurred speech and dizziness. Neurological symptoms can progress to partial paralysis; respiratory distress has been recorded. Recent research has implicated new species of harmful algal bloom organisms which produce brevetoxins, identified additional marine species which accumulate brevetoxins, and has provided additional information on the toxicity and analysis of brevetoxins. A review of the known epidemiology and recommendations for improved NSP prevention are presented.

Original languageEnglish
Pages (from-to)431-455
Number of pages25
JournalMarine Drugs
Volume6
Issue number3
DOIs
StatePublished - Sep 1 2008
Externally publishedYes

Fingerprint

Shellfish Poisoning
Harmful Algal Bloom
Shellfish
Paresthesia
Gulf of Mexico
Dinoflagellida
Sodium Channels
Neurotoxins
Dizziness
Ataxia
Lip
Tongue
Paralysis
Nausea
Vomiting
Disease Outbreaks
Mouth
brevetoxin
Epidemiology
Hospitalization

Keywords

  • Brevetoxins
  • Epidemiology
  • Harmful algal blooms (HABs)
  • Human health
  • Karenia brevis
  • Neurotoxic shellfish poisoning
  • NSP
  • Red tide

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Watkins, S. M., Reich, A., Fleming, L. E., & Hammond, R. (2008). Neurotoxic shellfish poisoning. Marine Drugs, 6(3), 431-455. https://doi.org/10.3390/md6030431

Neurotoxic shellfish poisoning. / Watkins, Sharon M.; Reich, Andrew; Fleming, Lora E.; Hammond, Roberta.

In: Marine Drugs, Vol. 6, No. 3, 01.09.2008, p. 431-455.

Research output: Contribution to journalArticle

Watkins, SM, Reich, A, Fleming, LE & Hammond, R 2008, 'Neurotoxic shellfish poisoning', Marine Drugs, vol. 6, no. 3, pp. 431-455. https://doi.org/10.3390/md6030431
Watkins SM, Reich A, Fleming LE, Hammond R. Neurotoxic shellfish poisoning. Marine Drugs. 2008 Sep 1;6(3):431-455. https://doi.org/10.3390/md6030431
Watkins, Sharon M. ; Reich, Andrew ; Fleming, Lora E. ; Hammond, Roberta. / Neurotoxic shellfish poisoning. In: Marine Drugs. 2008 ; Vol. 6, No. 3. pp. 431-455.
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