Neurotensin: Role in psychiatric and neurological diseases

Ricardo Cáceda, Becky Kinkead, Charles B. Nemeroff

Research output: Contribution to journalReview article

98 Scopus citations

Abstract

Neurotensin (NT), an endogenous brain-gut peptide, has a close anatomical and functional relationship with the mesocorticolimbic and neostriatal dopamine system. Dysregulation of NT neurotransmission in this system has been hypothesized to be involved in the pathogenesis of schizophrenia. Additionally, NT containing circuits have been demonstrated to mediate some of the mechanisms of action of antipsychotic drugs, as well as the rewarding and/or sensitizing properties of drugs of abuse. NT receptors have been suggested to be novel targets for the treatment of psychoses or drug addiction.

Original languageEnglish (US)
Pages (from-to)2385-2404
Number of pages20
JournalPeptides
Volume27
Issue number10
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Keywords

  • Antipsychotic drugs
  • Dopamine
  • Drugs of abuse
  • Neurotensin
  • Parkinson's disease
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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