Neurotensin

Role in psychiatric and neurological diseases

Ricardo Cáceda, Becky Kinkead, Charles Nemeroff

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Neurotensin (NT), an endogenous brain-gut peptide, has a close anatomical and functional relationship with the mesocorticolimbic and neostriatal dopamine system. Dysregulation of NT neurotransmission in this system has been hypothesized to be involved in the pathogenesis of schizophrenia. Additionally, NT containing circuits have been demonstrated to mediate some of the mechanisms of action of antipsychotic drugs, as well as the rewarding and/or sensitizing properties of drugs of abuse. NT receptors have been suggested to be novel targets for the treatment of psychoses or drug addiction.

Original languageEnglish
Pages (from-to)2385-2404
Number of pages20
JournalPeptides
Volume27
Issue number10
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Fingerprint

Neurotensin
Psychiatry
Neurotensin Receptors
Street Drugs
Synaptic Transmission
Psychotic Disorders
Antipsychotic Agents
Substance-Related Disorders
Dopamine
Brain
Schizophrenia
Peptides
Networks (circuits)
Pharmaceutical Preparations

Keywords

  • Antipsychotic drugs
  • Dopamine
  • Drugs of abuse
  • Neurotensin
  • Parkinson's disease
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Neurotensin : Role in psychiatric and neurological diseases. / Cáceda, Ricardo; Kinkead, Becky; Nemeroff, Charles.

In: Peptides, Vol. 27, No. 10, 01.10.2006, p. 2385-2404.

Research output: Contribution to journalArticle

Cáceda, Ricardo ; Kinkead, Becky ; Nemeroff, Charles. / Neurotensin : Role in psychiatric and neurological diseases. In: Peptides. 2006 ; Vol. 27, No. 10. pp. 2385-2404.
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