Neurotensin: Role in psychiatric and neurological diseases

Ricardo Cáceda, Becky Kinkead, Charles B. Nemeroff

Research output: Contribution to journalReview articlepeer-review

100 Scopus citations


Neurotensin (NT), an endogenous brain-gut peptide, has a close anatomical and functional relationship with the mesocorticolimbic and neostriatal dopamine system. Dysregulation of NT neurotransmission in this system has been hypothesized to be involved in the pathogenesis of schizophrenia. Additionally, NT containing circuits have been demonstrated to mediate some of the mechanisms of action of antipsychotic drugs, as well as the rewarding and/or sensitizing properties of drugs of abuse. NT receptors have been suggested to be novel targets for the treatment of psychoses or drug addiction.

Original languageEnglish (US)
Pages (from-to)2385-2404
Number of pages20
Issue number10
StatePublished - Oct 2006
Externally publishedYes


  • Antipsychotic drugs
  • Dopamine
  • Drugs of abuse
  • Neurotensin
  • Parkinson's disease
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience


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