Neurotensin (NT), an endogenous brain tridecapeptide, produces hypothermia after intracerebroventricular administration in rats and mice. The hypothermie potency of a series of structural analogues of neurotensin has been studied. [d-Arg9]-NT, NT9-13 and physalemin were devoid of hypothermie activity. The most potent peptides studied in reducing body temperature of cold-exposed rats were bombesin and [d-Tyr11]-NT. [d-Arg8]-NT, [Phe11]-NT, [d-Pro7]-NT, NT-MHMe [d-Pro10]-NT and NT8-13 possessed significant hypothermie activity, though the latter two compounds were the least active. These results indicate that the C-terminal end of the neurotensin molecule is essential for hypothermie activity.
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience