Neurotensin-induced hypothermia in the rat: Structure-activity studies

P. T. Loosen, C. B. Nemeroff, G. Bissette, G. B. Burnett, A. J. Prange, M. A. Lipton

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Abstract

Neurotensin (NT), an endogenous brain tridecapeptide, produces hypothermia after intracerebroventricular administration in rats and mice. The hypothermie potency of a series of structural analogues of neurotensin has been studied. [d-Arg9]-NT, NT9-13 and physalemin were devoid of hypothermie activity. The most potent peptides studied in reducing body temperature of cold-exposed rats were bombesin and [d-Tyr11]-NT. [d-Arg8]-NT, [Phe11]-NT, [d-Pro7]-NT, NT-MHMe [d-Pro10]-NT and NT8-13 possessed significant hypothermie activity, though the latter two compounds were the least active. These results indicate that the C-terminal end of the neurotensin molecule is essential for hypothermie activity.

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalNeuropharmacology
Volume17
Issue number2
DOIs
StatePublished - Feb 1978
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Loosen, P. T., Nemeroff, C. B., Bissette, G., Burnett, G. B., Prange, A. J., & Lipton, M. A. (1978). Neurotensin-induced hypothermia in the rat: Structure-activity studies. Neuropharmacology, 17(2), 109-113. https://doi.org/10.1016/0028-3908(78)90122-3