Neurotensin-induced antinociception in mice: Antagonism by thyrotropin-releasing hormone

A. J. Osbahr, C. B. Nemeroff, D. Luttinger, G. A. Mason, A. J. Prange

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

Neurotensin (NT), administered intracisternally to mice, produced significant dose-dependent antinociception in three analgesic tests: tail immersion, hot-plate and acetic acid writhing. Naloxone (1-5 mg/kg), an opiate antagonist administered i.p. 20 min before NT administration, did not significantly alter NT-induced antinociception in any of these tests; naloxone did significantly reverse β-endorphin-induced antinociception. However, centrally and peripherally administered thyrotropin-releasing hormone antagonized NT-induced (but not β-endorphin-induced) antinociception. Equimolar doses of another tripeptide (Pro-Leu-Gly-NH2; melanostatin) did not alter the effects of NT. The data obtained in this study confirm NT-induced antinociception, provide further evidence that NT does not activate naloxone-sensitive opiate receptors and demonstrate that this brain effect of NT is antagonized by thyrotropin-releasing hormone. These findings therefore support the hypothesis that NT and thyrotropin-releasing hormone are functional antagonists in the central nervous sytem.

Original languageEnglish (US)
Pages (from-to)645-651
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume217
Issue number3
StatePublished - Sep 21 1981
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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