Neurotensin: central nervous system effects of a hypothalamic peptide

Charles Nemeroff, Garth Bissette, Arthur J. Prange, Peter T. Loosen, T. Steven Barlow, Morris A. Lipton

Research output: Contribution to journalArticle

220 Citations (Scopus)

Abstract

The central administration of neurotensin, an endogenous hypothalamic tridecapeptide, produces a marked dose-related decrease in body temperature of mice and rats at an ambient temperature of 25 °C. This effect is even more pronounced when mice are placed at 4°C to increase the rate of decline of body temperature. Other sequelae observed after central administration of neurotensin are decreases in locomotor activity in rats and a marked dose-related enhancement in pentobarbital-induced mortality, sedation and hypothermia. This latter effect was shown to be due to a significant reduction in the metabolic degradation of the barbiturate. None of the above-mentioned effects are observed after peripheral neurotensin administration, suggesting that this peptide does not readily cross the blood-brain barrier. Neurotensin appears to be one of a growing list of neuropeptides that can affect CNS function.

Original languageEnglish
Pages (from-to)485-496
Number of pages12
JournalBrain Research
Volume128
Issue number3
DOIs
StatePublished - Jun 17 1977
Externally publishedYes

Fingerprint

Neurotensin
Central Nervous System
Peptides
Body Temperature
Pentobarbital
Locomotion
Hypothermia
Neuropeptides
Blood-Brain Barrier
Temperature
Mortality

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Nemeroff, C., Bissette, G., Prange, A. J., Loosen, P. T., Steven Barlow, T., & Lipton, M. A. (1977). Neurotensin: central nervous system effects of a hypothalamic peptide. Brain Research, 128(3), 485-496. https://doi.org/10.1016/0006-8993(77)90173-1

Neurotensin : central nervous system effects of a hypothalamic peptide. / Nemeroff, Charles; Bissette, Garth; Prange, Arthur J.; Loosen, Peter T.; Steven Barlow, T.; Lipton, Morris A.

In: Brain Research, Vol. 128, No. 3, 17.06.1977, p. 485-496.

Research output: Contribution to journalArticle

Nemeroff, C, Bissette, G, Prange, AJ, Loosen, PT, Steven Barlow, T & Lipton, MA 1977, 'Neurotensin: central nervous system effects of a hypothalamic peptide', Brain Research, vol. 128, no. 3, pp. 485-496. https://doi.org/10.1016/0006-8993(77)90173-1
Nemeroff C, Bissette G, Prange AJ, Loosen PT, Steven Barlow T, Lipton MA. Neurotensin: central nervous system effects of a hypothalamic peptide. Brain Research. 1977 Jun 17;128(3):485-496. https://doi.org/10.1016/0006-8993(77)90173-1
Nemeroff, Charles ; Bissette, Garth ; Prange, Arthur J. ; Loosen, Peter T. ; Steven Barlow, T. ; Lipton, Morris A. / Neurotensin : central nervous system effects of a hypothalamic peptide. In: Brain Research. 1977 ; Vol. 128, No. 3. pp. 485-496.
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