Neurotensin: central nervous system effects of a hypothalamic peptide

Charles B. Nemeroff, Garth Bissette, Arthur J. Prange, Peter T. Loosen, T. Steven Barlow, Morris A. Lipton

Research output: Contribution to journalArticlepeer-review

221 Scopus citations

Abstract

The central administration of neurotensin, an endogenous hypothalamic tridecapeptide, produces a marked dose-related decrease in body temperature of mice and rats at an ambient temperature of 25 °C. This effect is even more pronounced when mice are placed at 4°C to increase the rate of decline of body temperature. Other sequelae observed after central administration of neurotensin are decreases in locomotor activity in rats and a marked dose-related enhancement in pentobarbital-induced mortality, sedation and hypothermia. This latter effect was shown to be due to a significant reduction in the metabolic degradation of the barbiturate. None of the above-mentioned effects are observed after peripheral neurotensin administration, suggesting that this peptide does not readily cross the blood-brain barrier. Neurotensin appears to be one of a growing list of neuropeptides that can affect CNS function.

Original languageEnglish (US)
Pages (from-to)485-496
Number of pages12
JournalBrain Research
Volume128
Issue number3
DOIs
StatePublished - Jun 17 1977
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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