Neurotensin and dopamine interactions

E. B. Binder, B. Kinkead, M. J. Owens, Charles Nemeroff

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Interactions between the classical monoamine neurotransmitter dopamine (DA) and the peptide neurotransmitter neurotensin (NT) in the central nervous system (CNS) have now been investigated for over two decades. Interest in this topic has been sustained, primarily because of the potential clinical relevance of these interactions to schizophrenia and drug abuse. In the past five years, important new discoveries in the NT field have markedly expanded our previous database. Additional NT receptors have been cloned, and novel and refined techniques have contributed to a more detailed description of the anatomy of the CNS NT system. Additionally, lipophilic NT receptor antagonists, active in the CNS after peripheral administration, have rendered more facile the investigation of the physiologic importance of endogenous NT at electrophysiologic, neurochemical, and behavioral levels. In the present review, the discussion of NT/DA interactions will progress from a discussion of the anatomical interactions between these two systems, to electrophysiologic and neurochemical interactions, and finally to behavioral implications - always with focus toward the potential clinical relevance of the data. The discussion of interactions between NT and DA systems will be limited to those occurring within the CNS. Moreover, because the DA projections from the midbrain to the striatum account for the bulk of the DA innervation in the CNS, we will focus on NT/DA interactions within these brain regions. Last, because of the extensive literature on NT/DA interactions available in the rat, our discussion will be based primarily on studies using this species.

Original languageEnglish
Pages (from-to)453-486
Number of pages34
JournalPharmacological Reviews
Volume53
Issue number4
StatePublished - Dec 24 2001
Externally publishedYes

Fingerprint

Neurotensin
Dopamine
Central Nervous System
Neurotensin Receptors
Neurotransmitter Agents
Mesencephalon
Substance-Related Disorders
Anatomy
Schizophrenia
Databases
Peptides
Brain

ASJC Scopus subject areas

  • Pharmacology

Cite this

Binder, E. B., Kinkead, B., Owens, M. J., & Nemeroff, C. (2001). Neurotensin and dopamine interactions. Pharmacological Reviews, 53(4), 453-486.

Neurotensin and dopamine interactions. / Binder, E. B.; Kinkead, B.; Owens, M. J.; Nemeroff, Charles.

In: Pharmacological Reviews, Vol. 53, No. 4, 24.12.2001, p. 453-486.

Research output: Contribution to journalArticle

Binder, EB, Kinkead, B, Owens, MJ & Nemeroff, C 2001, 'Neurotensin and dopamine interactions', Pharmacological Reviews, vol. 53, no. 4, pp. 453-486.
Binder EB, Kinkead B, Owens MJ, Nemeroff C. Neurotensin and dopamine interactions. Pharmacological Reviews. 2001 Dec 24;53(4):453-486.
Binder, E. B. ; Kinkead, B. ; Owens, M. J. ; Nemeroff, Charles. / Neurotensin and dopamine interactions. In: Pharmacological Reviews. 2001 ; Vol. 53, No. 4. pp. 453-486.
@article{a1d1eab893734a66ad6f0522b4b0a0cf,
title = "Neurotensin and dopamine interactions",
abstract = "Interactions between the classical monoamine neurotransmitter dopamine (DA) and the peptide neurotransmitter neurotensin (NT) in the central nervous system (CNS) have now been investigated for over two decades. Interest in this topic has been sustained, primarily because of the potential clinical relevance of these interactions to schizophrenia and drug abuse. In the past five years, important new discoveries in the NT field have markedly expanded our previous database. Additional NT receptors have been cloned, and novel and refined techniques have contributed to a more detailed description of the anatomy of the CNS NT system. Additionally, lipophilic NT receptor antagonists, active in the CNS after peripheral administration, have rendered more facile the investigation of the physiologic importance of endogenous NT at electrophysiologic, neurochemical, and behavioral levels. In the present review, the discussion of NT/DA interactions will progress from a discussion of the anatomical interactions between these two systems, to electrophysiologic and neurochemical interactions, and finally to behavioral implications - always with focus toward the potential clinical relevance of the data. The discussion of interactions between NT and DA systems will be limited to those occurring within the CNS. Moreover, because the DA projections from the midbrain to the striatum account for the bulk of the DA innervation in the CNS, we will focus on NT/DA interactions within these brain regions. Last, because of the extensive literature on NT/DA interactions available in the rat, our discussion will be based primarily on studies using this species.",
author = "Binder, {E. B.} and B. Kinkead and Owens, {M. J.} and Charles Nemeroff",
year = "2001",
month = "12",
day = "24",
language = "English",
volume = "53",
pages = "453--486",
journal = "Pharmacological Reviews",
issn = "0031-6997",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "4",

}

TY - JOUR

T1 - Neurotensin and dopamine interactions

AU - Binder, E. B.

AU - Kinkead, B.

AU - Owens, M. J.

AU - Nemeroff, Charles

PY - 2001/12/24

Y1 - 2001/12/24

N2 - Interactions between the classical monoamine neurotransmitter dopamine (DA) and the peptide neurotransmitter neurotensin (NT) in the central nervous system (CNS) have now been investigated for over two decades. Interest in this topic has been sustained, primarily because of the potential clinical relevance of these interactions to schizophrenia and drug abuse. In the past five years, important new discoveries in the NT field have markedly expanded our previous database. Additional NT receptors have been cloned, and novel and refined techniques have contributed to a more detailed description of the anatomy of the CNS NT system. Additionally, lipophilic NT receptor antagonists, active in the CNS after peripheral administration, have rendered more facile the investigation of the physiologic importance of endogenous NT at electrophysiologic, neurochemical, and behavioral levels. In the present review, the discussion of NT/DA interactions will progress from a discussion of the anatomical interactions between these two systems, to electrophysiologic and neurochemical interactions, and finally to behavioral implications - always with focus toward the potential clinical relevance of the data. The discussion of interactions between NT and DA systems will be limited to those occurring within the CNS. Moreover, because the DA projections from the midbrain to the striatum account for the bulk of the DA innervation in the CNS, we will focus on NT/DA interactions within these brain regions. Last, because of the extensive literature on NT/DA interactions available in the rat, our discussion will be based primarily on studies using this species.

AB - Interactions between the classical monoamine neurotransmitter dopamine (DA) and the peptide neurotransmitter neurotensin (NT) in the central nervous system (CNS) have now been investigated for over two decades. Interest in this topic has been sustained, primarily because of the potential clinical relevance of these interactions to schizophrenia and drug abuse. In the past five years, important new discoveries in the NT field have markedly expanded our previous database. Additional NT receptors have been cloned, and novel and refined techniques have contributed to a more detailed description of the anatomy of the CNS NT system. Additionally, lipophilic NT receptor antagonists, active in the CNS after peripheral administration, have rendered more facile the investigation of the physiologic importance of endogenous NT at electrophysiologic, neurochemical, and behavioral levels. In the present review, the discussion of NT/DA interactions will progress from a discussion of the anatomical interactions between these two systems, to electrophysiologic and neurochemical interactions, and finally to behavioral implications - always with focus toward the potential clinical relevance of the data. The discussion of interactions between NT and DA systems will be limited to those occurring within the CNS. Moreover, because the DA projections from the midbrain to the striatum account for the bulk of the DA innervation in the CNS, we will focus on NT/DA interactions within these brain regions. Last, because of the extensive literature on NT/DA interactions available in the rat, our discussion will be based primarily on studies using this species.

UR - http://www.scopus.com/inward/record.url?scp=0035213478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035213478&partnerID=8YFLogxK

M3 - Article

C2 - 11734615

AN - SCOPUS:0035213478

VL - 53

SP - 453

EP - 486

JO - Pharmacological Reviews

JF - Pharmacological Reviews

SN - 0031-6997

IS - 4

ER -