Our finding that NT influences the phosphorylation of synaptosomal proteins demonstrates that protein phosphorylation-dephosphorylation must now be considered as a candidate mechanism for the transduction of the NT signal. As the current experiments did not include a protease inhibitor to prevent degradation of NT, we are currently refining the dose-response and time course of the NT-induced phosphorylation changes using such inhibitors. Work is also in progress to identify individual NT-sensitive phosphoprotein substrates and the second messenger systems (cAMP, cGMP, Ca2+-calmodulin, diacylglycerol) that mediate the NT message.
|Original language||English (US)|
|Number of pages||3|
|Journal||Annals of the New York Academy of Sciences|
|State||Published - May 1987|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science