Neurotensin Alters Phosphorylation of Neostriatal Proteins

SCOTT T. CAIN, CHARLES B. NEMEROFF

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Our finding that NT influences the phosphorylation of synaptosomal proteins demonstrates that protein phosphorylation-dephosphorylation must now be considered as a candidate mechanism for the transduction of the NT signal. As the current experiments did not include a protease inhibitor to prevent degradation of NT, we are currently refining the dose-response and time course of the NT-induced phosphorylation changes using such inhibitors. Work is also in progress to identify individual NT-sensitive phosphoprotein substrates and the second messenger systems (cAMP, cGMP, Ca2+-calmodulin, diacylglycerol) that mediate the NT message.

Original languageEnglish (US)
Pages (from-to)98-100
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume494
Issue number1
DOIs
StatePublished - May 1987
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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