Neurosteroids in the Pathophysiology and Treatment of Mood and Anxiety Disorders

Elizabeth C. Perkins, Donald J Newport

Research output: Contribution to journalReview article

Abstract

Purpose of reviewNeurosteroids have been implicated in the pathophysiology of mood, anxiety, and trauma-related disorders, as well as syndromes specific to women such as premenstrual syndrome, premenstrual dysphoric disorder, postpartum depression, peri- and post-menopausal depression. This review summarizes the role of neurosteroids in the neurobiology of stress and that of pharmaceuticals that modulate neurosteroids in the treatment of these disorders. Recent findingsNeurosteroids may provide novel treatments of mood and anxiety disorders. While endogenous neurosteroids have poor bioavailability, there are other means by which neurosteroid activity may be pharmacologically modulated. Various synthetic neurosteroids are under investigation. In addition, naturally produced exogenous molecules that positively modulate neurosteroid action at GABA A , as well as agents targeting enzymes that degrade or promote synthesis of neurosteroids, are being used to manipulate neurosteroid systems. SummaryNeurosteroids act on a wide variety of neuroreceptors, particularly GABA A , playing roles in both homeostasis and the pathophysiology of stress. There is evidence that many pharmaceuticals used for mood and anxiety disorders including antidepressants, antipsychotics, and mood stabilizers may be effective secondary to their ability to modulate neurosteroids. Synthetic versions of neurosteroids, as well as pharmaceuticals that act indirectly to increase synthesis of neurosteroids, are being studied as possible treatments for a variety of mood and anxiety disorders.

Original languageEnglish (US)
Pages (from-to)377-400
Number of pages24
JournalCurrent Treatment Options in Psychiatry
Volume5
Issue number4
DOIs
StatePublished - Dec 1 2018

Fingerprint

Anxiety Disorders
Mood Disorders
Neurotransmitter Agents
Therapeutics
gamma-Aminobutyric Acid
Pharmaceutical Preparations
Premenstrual Syndrome
Postpartum Depression
Aptitude
Neurobiology
Sensory Receptor Cells
Antidepressive Agents
Antipsychotic Agents
Biological Availability
Homeostasis
Anxiety
Depression

Keywords

  • Allopregnanolone
  • Anxiety
  • Depression
  • DHEA
  • Early life adversity
  • Estrogen
  • GABA
  • Neurosteroid
  • Progesterone

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Neurosteroids in the Pathophysiology and Treatment of Mood and Anxiety Disorders. / Perkins, Elizabeth C.; Newport, Donald J.

In: Current Treatment Options in Psychiatry, Vol. 5, No. 4, 01.12.2018, p. 377-400.

Research output: Contribution to journalReview article

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