TY - JOUR
T1 - Neuropsychological correlates of subjective fatigue in non-demented older adults and the moderating effect of physical activity
AU - Banerjee, Nikhil
AU - Slugh, Mitchell
AU - Kaur, Sonya
AU - Sun-Suslow, Ni
AU - McInerney, Katalina F.
AU - Sun, Xiaoyan
AU - Levin, Bonnie E.
N1 - Funding Information:
This work was supported by the McKnight Brain Institute.
Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/3/3
Y1 - 2020/3/3
N2 - This study examined the association between self-reported fatigue and neuropsychological performance in 167 middle-aged and older (age range: 50–91 years) adults without dementia. Participants completed the Fatigue Symptom Inventory, a comprehensive neuropsychological evaluation, and frailty assessment. Higher levels of fatigue were significantly associated with poorer attention/information processing, executive functioning, and psychomotor speed, even after controlling for depression, sleep quality, physical weakness, and other covariates. Participants endorsing moderate-severe fatigue faced higher odds (OR = 6.6, 95% CI = 1.1, 39.1) of exhibiting clinical attention/information processing impairments than those without. Moderation analyses showed that fatigue was related to select cognitive deficits among those reporting mean or lower levels of activity, but not high levels. These findings highlight fatigue as an important clinical marker of select cognitive deficits in non-demented older adults that is distinct from the common confounding conditions examined in this study. High levels of physical activity may buffer this relationship.
AB - This study examined the association between self-reported fatigue and neuropsychological performance in 167 middle-aged and older (age range: 50–91 years) adults without dementia. Participants completed the Fatigue Symptom Inventory, a comprehensive neuropsychological evaluation, and frailty assessment. Higher levels of fatigue were significantly associated with poorer attention/information processing, executive functioning, and psychomotor speed, even after controlling for depression, sleep quality, physical weakness, and other covariates. Participants endorsing moderate-severe fatigue faced higher odds (OR = 6.6, 95% CI = 1.1, 39.1) of exhibiting clinical attention/information processing impairments than those without. Moderation analyses showed that fatigue was related to select cognitive deficits among those reporting mean or lower levels of activity, but not high levels. These findings highlight fatigue as an important clinical marker of select cognitive deficits in non-demented older adults that is distinct from the common confounding conditions examined in this study. High levels of physical activity may buffer this relationship.
KW - Fatigue
KW - attention
KW - cognition
KW - older adults
KW - physical activity
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U2 - 10.1080/13825585.2019.1606889
DO - 10.1080/13825585.2019.1606889
M3 - Article
C2 - 31025596
AN - SCOPUS:85065061872
VL - 27
SP - 254
EP - 269
JO - Aging, Neuropsychology, and Cognition
JF - Aging, Neuropsychology, and Cognition
SN - 1382-5585
IS - 2
ER -