Abstract
This study examined the association between self-reported fatigue and neuropsychological performance in 167 middle-aged and older (age range: 50–91 years) adults without dementia. Participants completed the Fatigue Symptom Inventory, a comprehensive neuropsychological evaluation, and frailty assessment. Higher levels of fatigue were significantly associated with poorer attention/information processing, executive functioning, and psychomotor speed, even after controlling for depression, sleep quality, physical weakness, and other covariates. Participants endorsing moderate-severe fatigue faced higher odds (OR = 6.6, 95% CI = 1.1, 39.1) of exhibiting clinical attention/information processing impairments than those without. Moderation analyses showed that fatigue was related to select cognitive deficits among those reporting mean or lower levels of activity, but not high levels. These findings highlight fatigue as an important clinical marker of select cognitive deficits in non-demented older adults that is distinct from the common confounding conditions examined in this study. High levels of physical activity may buffer this relationship.
| Original language | English (US) |
|---|---|
| Journal | Aging, Neuropsychology, and Cognition |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- attention
- cognition
- Fatigue
- older adults
- physical activity
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology
- Experimental and Cognitive Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Neuropsychological correlates of subjective fatigue in non-demented older adults and the moderating effect of physical activity. / Banerjee, Nikhil; Slugh, Mitchell; Kaur, Sonya; Sun-Suslow, Ni; McInerney, Katalina F.; Sun, Xiaoyan; Levin, Bonnie.
In: Aging, Neuropsychology, and Cognition, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Neuropsychological correlates of subjective fatigue in non-demented older adults and the moderating effect of physical activity
AU - Banerjee, Nikhil
AU - Slugh, Mitchell
AU - Kaur, Sonya
AU - Sun-Suslow, Ni
AU - McInerney, Katalina F.
AU - Sun, Xiaoyan
AU - Levin, Bonnie
PY - 2019/1/1
Y1 - 2019/1/1
N2 - This study examined the association between self-reported fatigue and neuropsychological performance in 167 middle-aged and older (age range: 50–91 years) adults without dementia. Participants completed the Fatigue Symptom Inventory, a comprehensive neuropsychological evaluation, and frailty assessment. Higher levels of fatigue were significantly associated with poorer attention/information processing, executive functioning, and psychomotor speed, even after controlling for depression, sleep quality, physical weakness, and other covariates. Participants endorsing moderate-severe fatigue faced higher odds (OR = 6.6, 95% CI = 1.1, 39.1) of exhibiting clinical attention/information processing impairments than those without. Moderation analyses showed that fatigue was related to select cognitive deficits among those reporting mean or lower levels of activity, but not high levels. These findings highlight fatigue as an important clinical marker of select cognitive deficits in non-demented older adults that is distinct from the common confounding conditions examined in this study. High levels of physical activity may buffer this relationship.
AB - This study examined the association between self-reported fatigue and neuropsychological performance in 167 middle-aged and older (age range: 50–91 years) adults without dementia. Participants completed the Fatigue Symptom Inventory, a comprehensive neuropsychological evaluation, and frailty assessment. Higher levels of fatigue were significantly associated with poorer attention/information processing, executive functioning, and psychomotor speed, even after controlling for depression, sleep quality, physical weakness, and other covariates. Participants endorsing moderate-severe fatigue faced higher odds (OR = 6.6, 95% CI = 1.1, 39.1) of exhibiting clinical attention/information processing impairments than those without. Moderation analyses showed that fatigue was related to select cognitive deficits among those reporting mean or lower levels of activity, but not high levels. These findings highlight fatigue as an important clinical marker of select cognitive deficits in non-demented older adults that is distinct from the common confounding conditions examined in this study. High levels of physical activity may buffer this relationship.
KW - attention
KW - cognition
KW - Fatigue
KW - older adults
KW - physical activity
UR - http://www.scopus.com/inward/record.url?scp=85065061872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065061872&partnerID=8YFLogxK
U2 - 10.1080/13825585.2019.1606889
DO - 10.1080/13825585.2019.1606889
M3 - Article
AN - SCOPUS:85065061872
JO - Aging, Neuropsychology, and Cognition
JF - Aging, Neuropsychology, and Cognition
SN - 1382-5585
ER -