Neuropsychological correlates of central monoamine function in chronic schizophrenia: relationship between CSF metabolites and cognitive function

RenéS S. Kahn, Philip D. Harvey, Michael Davidson, Richard S.E. Keefe, Seth Apter, John M. Neale, Richard C. Mohs, Kenneth L. Davis

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Schizophrenia is associated with multiple cognitive deficits which in turn may be related to abnormal dopamine (DA) function. To examine possible associations between cognitive dysfunction and central DA activity in schizophrenia, neuropsychological measures (visuospatial and verbal recall; performance on the Wisconsin Card Sort Test (WCST); visuospatial perception) were examined in 17 drug-free male schizophrenic patients and related to cerebrospinal fluid concentrations of the metabolites of dopamine (homovanillic acid (HVA)), serotonin, and norepinephrine. CSF HVA concentrations were correlated with the ability to recall visuospatial information, with attention to verbal tasks, and with WCST performance (low CSF HVA concentrations predicting poor performance on these tests) but not with the ability to recall verbally presented material and visuospatial perception. These data are consistent with earlier results suggesting that (cortical) DA function is associated with recall and retrieval of visuospatial information and with WCST performance.

Original languageEnglish (US)
Pages (from-to)217-224
Number of pages8
JournalSchizophrenia Research
Volume11
Issue number3
DOIs
StatePublished - Feb 1994
Externally publishedYes

Keywords

  • (Schizophrenia)
  • Cognition
  • CSF
  • Dopamine
  • Memory

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

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