Neuropsychological correlates of brain atrophy in Huntington's disease: a magnetic resonance imaging study

S. E. Starkstein, J. Brandt, F. Bylsma, C. Peyser, M. Folstein, S. E. Folstein

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Magnetic resonance imaging and a comprehensive cognitive evaluation were carried out in a series of 29 patients with mild to moderate Huntington's disease (HD). A factor analysis of the neuropsychological test scores provided three factors: a memory/speed-of-processing factor, a "frontal" factor, and a response inhibition factor. The memory/speed factor correlated significantly with measures of caudate atrophy, frontal atrophy, and atrophy of the left (but not the right) sylvian cistern. There were no significant correlations between the "frontal" or response inhibition factors and measures of cortical or subcortical brain atrophy. Our findings confirm that subcortical atrophy is significantly correlated with specific cognitive deficits in HD, and demonstrate that cortical atrophy also has important association with the cognitive deficits of patients with HD.

Original languageEnglish (US)
Pages (from-to)487-489
Number of pages3
JournalNeuroradiology
Volume34
Issue number6
DOIs
StatePublished - Nov 1992

Keywords

  • Brain atrophy
  • Huntington's disease
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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    Starkstein, S. E., Brandt, J., Bylsma, F., Peyser, C., Folstein, M., & Folstein, S. E. (1992). Neuropsychological correlates of brain atrophy in Huntington's disease: a magnetic resonance imaging study. Neuroradiology, 34(6), 487-489. https://doi.org/10.1007/BF00598956