TY - JOUR
T1 - Neuropsychological and neuroradiological correlates in Huntington's disease
AU - Starkstein, Sergio E.
AU - Brandt, Jason
AU - Folstein,, Susan
AU - Strauss, Milton
AU - Berthier, Marcelo L.
AU - Pearlson, Godfrey D.
AU - Wong, Dean
AU - Mcdonnell, Anne
AU - Folstein, Marshal
PY - 1988
Y1 - 1988
N2 - Measurements of cortical and subcortical atrophy were made on CT scans of 34 patients with Huntington's disease. Significant correlations were found between the bicaudate ratio (BCR) and an eye movement scale (r = 0 44, p < 001), and activities of daily living scale (r = 0-57, p < 0-001) and the Mini-Mental State Exam (r = 0A49, p < 0-01). No correlations were found between BCR values and severity of chorea or voluntary motor impairment. A detailed neuropsychological evaluation of 18 Huntington's disease patients showed significant correlations between the BCR and Symbol Digit Modalities test (r = 0 65, p < 0-01), and parts A (r = 0-72, p < 0-001) and B (r = 0-80, p < 0 0001) of the Trail Making Test. These data support work in primates that demonstrates the role of the caudate nucleus in cognitive and oculomotor functions, but not in motor control (which is governed by putamino-subthalamic systems). The specific cognitive skills correlated with caudate atrophy in Huntington's disease are those reported in primate work to be served by the frontal-caudate loop system: eye movements, conceptual tracking, set shifting and psychomotor speed.
AB - Measurements of cortical and subcortical atrophy were made on CT scans of 34 patients with Huntington's disease. Significant correlations were found between the bicaudate ratio (BCR) and an eye movement scale (r = 0 44, p < 001), and activities of daily living scale (r = 0-57, p < 0-001) and the Mini-Mental State Exam (r = 0A49, p < 0-01). No correlations were found between BCR values and severity of chorea or voluntary motor impairment. A detailed neuropsychological evaluation of 18 Huntington's disease patients showed significant correlations between the BCR and Symbol Digit Modalities test (r = 0 65, p < 0-01), and parts A (r = 0-72, p < 0-001) and B (r = 0-80, p < 0 0001) of the Trail Making Test. These data support work in primates that demonstrates the role of the caudate nucleus in cognitive and oculomotor functions, but not in motor control (which is governed by putamino-subthalamic systems). The specific cognitive skills correlated with caudate atrophy in Huntington's disease are those reported in primate work to be served by the frontal-caudate loop system: eye movements, conceptual tracking, set shifting and psychomotor speed.
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U2 - 10.1136/jnnp.51.10.1259
DO - 10.1136/jnnp.51.10.1259
M3 - Article
C2 - 2976080
AN - SCOPUS:0023813331
VL - 51
SP - 1259
EP - 1263
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 10
ER -