Neuropsychological and neuroradiological correlates in Huntington's disease

Sergio E. Starkstein, Jason Brandt, Susan Folstein,, Milton Strauss, Marcelo L. Berthier, Godfrey D. Pearlson, Dean Wong, Anne Mcdonnell, Marshal Folstein

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Abstract

Measurements of cortical and subcortical atrophy were made on CT scans of 34 patients with Huntington's disease. Significant correlations were found between the bicaudate ratio (BCR) and an eye movement scale (r = 0 44, p < 001), and activities of daily living scale (r = 0-57, p < 0-001) and the Mini-Mental State Exam (r = 0A49, p < 0-01). No correlations were found between BCR values and severity of chorea or voluntary motor impairment. A detailed neuropsychological evaluation of 18 Huntington's disease patients showed significant correlations between the BCR and Symbol Digit Modalities test (r = 0 65, p < 0-01), and parts A (r = 0-72, p < 0-001) and B (r = 0-80, p < 0 0001) of the Trail Making Test. These data support work in primates that demonstrates the role of the caudate nucleus in cognitive and oculomotor functions, but not in motor control (which is governed by putamino-subthalamic systems). The specific cognitive skills correlated with caudate atrophy in Huntington's disease are those reported in primate work to be served by the frontal-caudate loop system: eye movements, conceptual tracking, set shifting and psychomotor speed.

Original languageEnglish (US)
Pages (from-to)1259-1263
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume51
Issue number10
DOIs
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Starkstein, S. E., Brandt, J., Folstein, S., Strauss, M., Berthier, M. L., Pearlson, G. D., Wong, D., Mcdonnell, A., & Folstein, M. (1988). Neuropsychological and neuroradiological correlates in Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry, 51(10), 1259-1263. https://doi.org/10.1136/jnnp.51.10.1259