Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells

Frank Schuettauf, David Zurakowski, Kristine Quinto, Meghana A. Varde, Dorothea Besch, Alan Laties, Ralph Anderson, Rong Wen

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background: Premature neuronal cell death is a feature of numerous central nervous system and eye diseases, including glaucoma. Neurons (including retinal ganglion cells, RGCs) are protected by several neurotrophic factors, among those the IL-6 family of cytokines. Lately, a novel member of the IL-6 family of cytokines has been identified and cloned. This cytokine is known as novel neurotrophin-1/ B-cell-stimulating factor-3 (NNT-1/BSF-3) or cardiotrophin-like cytokine (CLC). It shows neurotrophic as well as B-cell stimulatory effects. Methods: In this study, the neuroprotective properties of CLC on RGC loss in vivo were investigated. Results: CLC significantly protected RGCs from degeneration in both chosen models of retinal neuronal damage: optic nerve crush (P<0.01) and N-methyl-D-aspartate (NMDA) injection (P<0.001). Conclusions: CLC shows neuroprotective effects on RGCs in vivo and might be a treatment option for chronic neurodegenerative eye diseases such as glaucoma. Clinical feasibility for the substance requires further investigation since the immunomodulatory and possible adverse effects have not yet been thoroughly characterized.

Original languageEnglish (US)
Pages (from-to)1036-1042
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume243
Issue number10
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

Keywords

  • Cytokines
  • Excitotoxicity
  • Neuroprotection
  • Opticnerve crush
  • Retinal ganglion cells

ASJC Scopus subject areas

  • Ophthalmology

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