Neuroprotective effects of bone morphogenetic protein 7 (BMP7) treatment after spinal cord injury

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Bone morphogenetic protein 7 (BMP7) has been shown to ameliorate reduced dendritic growth induced by glutamate excitotoxicity in neuronal tissue cultures and/or provide an enhancement of functional recovery in central nervous system (CNS) injury. BMP7 expression is modulated by spinal cord injury (SCI), but the molecular mechanisms involved in neuroprotection have not been clearly defined. Here, we show that BMP7 treatment of rats subjected to mild cervical SCI significantly increased the pro-survival mitogen-activated protein kinase-38 (MAPK-38) pathway and levels of N-methyl-d-aspartate receptor 1 (NMDAR-1) resulting in a significant increase in neuronal sparing in the ventral horn of the spinal cord. Moreover, BMP7 was neuroprotective against glutamate-mediated excitotoxicity in cultured cortical neurons. These studies show that BMP7 administration may be used as a therapeutic strategy to reduce the damaging excitotoxic effects following SCI.

Original languageEnglish (US)
Pages (from-to)226-229
Number of pages4
JournalNeuroscience Letters
Volume465
Issue number3
DOIs
StatePublished - Nov 20 2009

Keywords

  • Bone morphogenetic protein 7
  • Glutamate excitotoxicity
  • MAPK signaling
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)

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