Neuroprotective effect of the AMPA receptor antagonist LY-293558 in focal cerebral ischemia in the cat

R. Bullock, D. I. Graham, S. Swanson, J. McCulloch

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

The effects of the glutamate α-amino-3-hydroxy 5-methyl-4-isoxazole propionate (AMPA) receptor antagonist LY-293558 in reducing ischemic brain damage have been assessed in halothane-anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of one middle cerebral artery, and the animals were killed 6 h later. The amount of early irreversible ischemic damage was assessed at 16 predetermined stereotactic planes by an observer blinded to treatment paradigm employed. Treatment with LY-293558 (15 mg/kg i.v., plus infusion of 7 mg/kg/h) initiated 30 min prior to middle cerebral artery occlusion reduced significantly (p < 0.02) the volume of ischemic damage (from 3.423 ± 212 mm3 of the cerebral hemisphere in vehicle-treated cats to 2,822 ± 569 mm3 in LY-293558-treated cats). The present data demonstrate that an AMPA receptor antagonist can reduce focal ischemic damage in a gyrencephalic species in which key physiological variables have been controlled and monitored throughout the postischemic period. These data provide additional support for the clinical evaluation of AMPA receptor antagonists in focal cerebral ischemia in humans.

Original languageEnglish (US)
Pages (from-to)466-471
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume14
Issue number3
DOIs
StatePublished - May 1994

Keywords

  • Cerebral ischemia
  • Cerebrovascular disease
  • Glutamate

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

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