Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats

Ludmila Belayev, Isabel Saul, Pil W. Huh, Nicoletta Finotti, Weizhao Zhao, Raul Busto, Myron D. Ginsberg

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (25% HSA) or vehicle (0.9% NaCl) was administered i.v. 5 min after termination of ischemia. HSA-treated rats showed significantly improved neurological deficits throughout a 7-day survival period. Histologically, HSA-treated rats showed 2.4- to 5.3-fold increases in numbers of surviving CA1 hippocampal pyramidal neurons compared to saline-treated animals. These results document that high-dose albumin therapy instituted 5 min after global ischemia significantly improves neurological score and reduces histological damage. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)107-111
Number of pages5
JournalBrain Research
Volume845
Issue number1
DOIs
StatePublished - Oct 16 1999

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Keywords

  • Albumin
  • Global cerebral ischemia
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

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