Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats

Ludmila Belayev; Isabel Saul; Pil W. Huh; Nicoletta Finotti; Weizhao Zhao; Raul Busto; Myron D. Ginsberg

doi:10.1016/S0006-8993(99)01952-6

Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats

Ludmila Belayev, Isabel Saul, Pil W. Huh, Nicoletta Finotti, Weizhao Zhao, Raul Busto, Myron D. Ginsberg

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (25% HSA) or vehicle (0.9% NaCl) was administered i.v. 5 min after termination of ischemia. HSA-treated rats showed significantly improved neurological deficits throughout a 7-day survival period. Histologically, HSA-treated rats showed 2.4- to 5.3-fold increases in numbers of surviving CA1 hippocampal pyramidal neurons compared to saline-treated animals. These results document that high-dose albumin therapy instituted 5 min after global ischemia significantly improves neurological score and reduces histological damage. Copyright (C) 1999 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	107-111
Number of pages	5
Journal	Brain Research
Volume	845
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(99)01952-6
State	Published - Oct 16 1999

Keywords

Albumin
Global cerebral ischemia
Neuroprotection
Stroke

ASJC Scopus subject areas

Neuroscience(all)

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title = "Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats",

abstract = "The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (25% HSA) or vehicle (0.9% NaCl) was administered i.v. 5 min after termination of ischemia. HSA-treated rats showed significantly improved neurological deficits throughout a 7-day survival period. Histologically, HSA-treated rats showed 2.4- to 5.3-fold increases in numbers of surviving CA1 hippocampal pyramidal neurons compared to saline-treated animals. These results document that high-dose albumin therapy instituted 5 min after global ischemia significantly improves neurological score and reduces histological damage. Copyright (C) 1999 Elsevier Science B.V.",

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AU - Belayev, Ludmila

AU - Saul, Isabel

AU - Huh, Pil W.

AU - Finotti, Nicoletta

AU - Zhao, Weizhao

AU - Busto, Raul

AU - Ginsberg, Myron D.

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N2 - The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (25% HSA) or vehicle (0.9% NaCl) was administered i.v. 5 min after termination of ischemia. HSA-treated rats showed significantly improved neurological deficits throughout a 7-day survival period. Histologically, HSA-treated rats showed 2.4- to 5.3-fold increases in numbers of surviving CA1 hippocampal pyramidal neurons compared to saline-treated animals. These results document that high-dose albumin therapy instituted 5 min after global ischemia significantly improves neurological score and reduces histological damage. Copyright (C) 1999 Elsevier Science B.V.

AB - The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (25% HSA) or vehicle (0.9% NaCl) was administered i.v. 5 min after termination of ischemia. HSA-treated rats showed significantly improved neurological deficits throughout a 7-day survival period. Histologically, HSA-treated rats showed 2.4- to 5.3-fold increases in numbers of surviving CA1 hippocampal pyramidal neurons compared to saline-treated animals. These results document that high-dose albumin therapy instituted 5 min after global ischemia significantly improves neurological score and reduces histological damage. Copyright (C) 1999 Elsevier Science B.V.

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