Neurophysiology of itch

G. Yosipovitch, Y. Ishiuji

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A subset of nociceptive histamine sensitive C neurons has been demonstrated to be dedicated for transmission of itch. Histamine independent nocicpetive C nerves that are mechanosensitive are capable of transmitting itch. Central pathways are involved in itch transmission both spinally and in the brain. Chronic itch shares similar patterns to chronic pain. Both central and peripheral mediators are important in pruritus. Neurotrophic factors, particularly NGF, have a role in chronic itch.

Original languageEnglish (US)
Title of host publicationNeuroimmunology of the Skin
Subtitle of host publicationBasic Science to Clinical Practice
PublisherSpringer Berlin Heidelberg
Pages179-186
Number of pages8
ISBN (Print)9783540359869
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Yosipovitch, G., & Ishiuji, Y. (2009). Neurophysiology of itch. In Neuroimmunology of the Skin: Basic Science to Clinical Practice (pp. 179-186). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-35989-0_16