Neurophysiology of itch

G. Yosipovitch, Y. Ishiuji

Research output: Chapter in Book/Report/Conference proceedingChapter


A subset of nociceptive histamine sensitive C neurons has been demonstrated to be dedicated for transmission of itch. Histamine independent nocicpetive C nerves that are mechanosensitive are capable of transmitting itch. Central pathways are involved in itch transmission both spinally and in the brain. Chronic itch shares similar patterns to chronic pain. Both central and peripheral mediators are important in pruritus. Neurotrophic factors, particularly NGF, have a role in chronic itch.

Original languageEnglish (US)
Title of host publicationNeuroimmunology of the Skin
Subtitle of host publicationBasic Science to Clinical Practice
PublisherSpringer Berlin Heidelberg
Number of pages8
ISBN (Print)9783540359869
StatePublished - Dec 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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