A subset of nociceptive histamine sensitive C neurons has been demonstrated to be dedicated for transmission of itch. Histamine independent nocicpetive C nerves that are mechanosensitive are capable of transmitting itch. Central pathways are involved in itch transmission both spinally and in the brain. Chronic itch shares similar patterns to chronic pain. Both central and peripheral mediators are important in pruritus. Neurotrophic factors, particularly NGF, have a role in chronic itch.
|Original language||English (US)|
|Title of host publication||Neuroimmunology of the Skin|
|Subtitle of host publication||Basic Science to Clinical Practice|
|Publisher||Springer Berlin Heidelberg|
|Number of pages||8|
|State||Published - Dec 1 2009|
ASJC Scopus subject areas