Neuropharmacological actions of the superactive agonist analog D-Trp-6-LH-RH after peripheral injection into mice

T. Kádár, G. Telegdy, A. V. Schally

Research output: Contribution to journalArticle

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Abstract

The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 μg/kg. D-Trp-6-LH-RH doses of 10 μg/kg and higher induced significant analgesic effects in the hot-plate and tail-flick tests, and decreased the open-field parameters (ambulation, rearing, grooming). The 100 and 1000 μg/kg doses increased the latencies of picrotoxin-induced seizures, significantly inhibited apomorphine-induced cage climbing and also exerted a cataleptogenic effect. The results indicate that this agonist analog of LH-RH has an inhibitory effect on the central nervous system, and the mechanism of its action may involve dopaminergic transmission and/or endogenous opiates.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalNeuropeptides
Volume17
Issue number2
DOIs
StatePublished - Oct 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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